We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Elevated Fructosamine Levels Associated with Increased PJI Risk

By LabMedica International staff writers
Posted on 24 Nov 2020
Print article
Image: Elevated fructosamine levels were associated with increased periprosthetic joint infection risk (Photo courtesy of Kristine Houck, MA).
Image: Elevated fructosamine levels were associated with increased periprosthetic joint infection risk (Photo courtesy of Kristine Houck, MA).
Periprosthetic joint infection (PJI) is the most serious complication that lowers the quality of patients’ life by elevating the patients’ burden of cost and affecting the outcome of total joint arthroplasty.

The fructosamine test is a measurement of glycated protein, mainly albumin (the main protein in the blood). When glucose levels in the blood are elevated over a period of time, glucose molecules permanently combine with proteins in the blood in a process called glycation.

Clinical scientists at the Rothman Orthopaedic Institute (Orlando, FL, USA) evaluated in a prospective multi-institutional study preoperative fructosamine and HbA1c levels in patients who had elective total hip arthroplasty (THA) from November 2017 to August 2018. The total patient cohorts included 1,212 patients and patients with and without diabetes were enrolled. The teams assessed fructosamine and HbA1c levels two to three weeks preoperatively. Adverse outcomes, such as PJI, wound complications, readmission and mortality, were assessed at one year postoperatively. A fructosamine level greater than 293 mol/L was defined as inadequate glycemic control and as a predictor for adverse outcomes.

Overall, 960 patients were available for follow-up at 1 year, at which time 3.5% of patients showed inadequate glycemic control based on fructosamine value. This was an unexpected finding as among patients with elevated fructosamine, 85% were unaware they had pre-diabetes and 42% were unaware they had diabetes. The PJI and mortality rates were six times higher in patients with high fructosamine. Readmission rates were five times higher in patients with high fructosamine. Patients with high fructosamine groups had PJI rates of almost 10% and readmission rates of 16%.

Noam Shohat, MD, an orthopedic surgeon and lead author of the study, said, “Fructosamine is inexpensive and readily available marker. It is better reflects the glucose levels prior to surgery. So, it is a better reflector and predictor of outcomes and responds quicker to treatment. For those with levels above 293 mol/L, we strongly encourage you to reconsider the need for surgery.”

The authors concluded that the association between high fructosamine levels and increased risk for PJI was statistically significant after adjustment for age, comorbidities and preoperative HbA1c levels in a regression analysis. The study was presented at the American Association of Hip and Knee Surgeons Annual Hybrid Meeting held November 5-8, 2020 in Dallas, TX, USA.

Related Links:
Rothman Orthopaedic Institute

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.