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Rapid Antigen COVID-19 Tests Not Keeping Pace with Variants of Concern

By LabMedica International staff writers
Posted on 06 May 2022
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Image: Rapid antigen tests remain a useful tool for detection of COVID-19 (Photo courtesy of Pexels)
Image: Rapid antigen tests remain a useful tool for detection of COVID-19 (Photo courtesy of Pexels)

Rapid antigen tests for the diagnosis of COVID-19 are slightly less accurate than the genetic tests administered by healthcare professionals, although their ease-of-use allows the general public to monitor themselves for COVID-19 infections at home and make timely decisions to help stop the spread. The home tests, however, were developed for use with the original SARS-CoV-2 viral strain that emerged late in 2019. Since then, the virus has evolved countless times, and several viral variants of concern have emerged, including the highly infectious delta and omicron variants that swept across the world. Now a new study suggests that while rapid antigen tests remain a useful tool for the detection of COVID-19 infections, continuous assessment and updating is likely needed in the context of variants of concern.

In the recent study, scientists at the Harvard T.H. Chan School of Public Health (Boston, MA, USA) and Beth Israel Deaconess (Boston, MA, USA) used live virus culture to assess how well four rapid antigen tests are able to detect these COVID variants of concern. Using three strains of cultured live virus, the team assessed differences in the limits of detection (LoD) - the smallest amount of viral antigen detectable at 95% certainty – of four commercially available rapid antigen tests. The researchers found that all four tests were as sensitive to the Omicron variant, if not more, as they were to original SARS-CoV-2 viral strain, known as WA1. Three tests, however, showed less sensitivity to the Delta strain, with only one demonstrating equal detection of all three strains.

“Unlike the sensitive molecular tests that detect multiple SARS-CoV-2 genes, rapid antigen tests target a single viral protein,” said James Kirby, MD, director of the Clinical Microbiology Laboratory at BIDMC. “As the pandemic continues, however, some hypothesize that the performance of available antigen test may vary among the COVID variants of concern.”

“We expect that the observed loss in Delta sensitivity could have resulted in a 20% or more loss of detection in potentially infectious individuals – nevertheless, the most infectious individuals still should have been detected,” added Kirby, also a professor of pathology at Harvard Medical School. “However, our findings suggest that antigen test performance needs to be reevaluated for emerging variants to ensure they still meet the intended public health testing goals of the pandemic.”

Related Links:
Harvard T.H. Chan School of Public Health 
Beth Israel Deaconess 

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