We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics- Hematology Division

Download Mobile App





New Diagnostic Device Identifies COVID-19 Patients at Risk of Potentially Lethal Cytokine Storm

By LabMedica International staff writers
Posted on 19 Feb 2021
Print article
Image: The  Immuno-storm chip is about the size of a 20c coin (Photo courtesy of AIBN)
Image: The Immuno-storm chip is about the size of a 20c coin (Photo courtesy of AIBN)
Researchers have developed a diagnostic device, called an Immuno-storm chip, that could identify which cancer and COVID-19 patients are at risk of a potentially lethal ‘cytokine storm’.

The device was invented by scientists from the Australian Institute for Bioengineering and Nanotechnology (AIBN) at The University of Queensland (Queensland, Australia) and could help healthcare workers triage and closely monitor high risk patients and to begin treatment much earlier.

Cytokines are small proteins that act as messengers between cells in the immune system. They play a critical role in triggering inflammation by stimulating the movement of immune cells toward sites of injury or infection. However, if the release of cytokines becomes uncontrolled, this causes hyperinflammation which damages tissue. This, in turn, causes more cytokines to be released in a vicious, potentially lethal cycle called a ‘cytokine storm’. Cytokine storms can arise during a variety of diseases, as well as in response to immune-therapies. Unfortunately, it’s very difficult to predict who will develop a cytokine storm. Until recently, they were thought to arise very suddenly, but there is now evidence that a very faint but distinctive pattern of cytokines begins to emerge several days before the full-blown storm.

Scientists at the AIBN have developed a nanotechnology device, called an Immuno-storm chip, that can detect this early warning signal on a miniaturized platform with minimal sample. They designed a nanoscale array of gold pillars to which they attached antibodies that stick to specific cytokines in blood. If these cytokines are present in a blood sample as small as a single drop, they will bind to the gold ‘nanopillars’. These captured cytokines are then detected by gold-silver ‘nanotag’ particles. The team designed these nanotags to emit light whenever they encounter a cytokine. The chip’s small size - about the size of a SIM card - meant the diagnostic technology could eventually be made relatively portable.

“Whether in a cancer treatment setting or when monitoring infectious diseases such as acute COVID-19, long-haul COVID-19 and sepsis, the Immuno-storm chip could provide critical medical information that guides important clinical decisions. Critically, it could inform doctors to begin, or to ease off treatments, by accurately monitoring the patient’s immune response before it goes crazy,” said Professor Matt Trau, a researcher AIBN. “Detection of the detailed cytokine signature for vulnerable COVID-19 patients with the Immuno-storm chip could also be used to personalize the therapy of these patients, tuned in to alleviate their specific excessive immune system response.”

Related Links:
The University of Queensland

Gold Supplier
SARS-CoV-2 S-IgG Antibody Assay
Lumipulse G SARS-CoV-2 S-IgG
New
Undercounter Laboratory Refrigerator
iLR105-GX
New
IgG/IgF IVD Test
ImmuneCheck IgG/IgF
New
Silver Supplier
COVID-19 Ag Self Test
OnSite COVID-19 Ag Self Test

Print article

Channels

Clinical Chem.

view channel
Image: Illustration is of the Vertical Auto Profile (VAP) Lipid test with clear demarcation of the different lipoprotein classes and subclasses. (Photo courtesy of VAP Diagnostics Laboratory)

Lipoprotein(a) Concentrations Correlate With LDL-C in Diabetic Children

Cardiovascular disease (CVD) is a significant cause of mortality in those with diabetes. Increased apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C) have been shown in pediatric patients... Read more

Molecular Diagnostics

view channel
Image: Model of the PD-1 (Programmed cell death protein 1) protein. Only a subset of recurrent glioblastomas respond to anti-PD-1 immunotherapy (Photo courtesy of Wikimedia Commons)

Biomarker Predicts Potential Benefit of Checkpoint Inhibitor Therapy for Brain Cancer Patients

A phosphorylated form of ERK (extracellular signal-regulated kinase) protein has been identified as a biomarker that may be used to predict which brain cancer patients might benefit from checkpoint inhibitor... Read more

Hematology

view channel
Image: The UniCel DxH 800 Coulter Cellular Analysis System (Photo courtesy of Beckman Coulter)

Monocyte Distribution Width Predicts Sepsis in Critically Ill Patients

Sepsis has been reported as a major cause of increased morbidity, length of stay and mortality among patients hospitalized in Intensive Care Units (ICUs) for any cause. The survival of patients developing... Read more

Immunology

view channel
Image: Procartaplex Immunoassays Kits are based on the principles of a sandwich ELISA, using two highly specific antibodies binding to different epitopes of one protein to quantitate all protein targets simultaneously (Photo courtesy of Thermo Fisher Scientific)

Assay Developed for Patient-Specific Monitoring and Treatment for Ovarian Cancer

Tumors can influence peripheral immune macroenvironment, thereby creating opportunities for non-invasive serum/plasma immunobiomarkers for immunostratification and immunotherapy designing.... Read more

Microbiology

view channel
Image: Clinical metagenomics (CMg) using nanopore sequencing (Photo courtesy of Oxford Nanopore Technologies)

Same Day Test Identifies Secondary Infections in COVID-19 Patients

The intensive care unit (ICU) is a dynamic environment with frequent staff-patient contact for invasive monitoring, interventions and personal care that together introduce the risk of secondary or nosocomial... Read more

Pathology

view channel
Image: The Ventana BenchMark Ultra autostainer is for cancer diagnostics with automation and the test menu include IHC, ISH, and FITC tests (Photo courtesy of Ventana Medical System)

Specific Biomarker Investigated for Triple-Negative Breast Cancer Diagnosis

Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression and comprises a heterogeneous... Read more

Technology

view channel
Image: PKeye Workflow Monitor System (Photo courtesy of PerkinElmer, Inc.)

PerkinElmer’s New Cloud-Based Platform Enables Laboratory Personnel to Remotely Manage Its Instruments in Real-Time

PerkinElmer, Inc. (Waltham, MA; USA) has launched its PKeye Workflow Monitor, a cloud-based platform enabling laboratory personnel to remotely manage and monitor their PerkinElmer instruments and workflows... Read more

Industry

view channel
Illustration

Global HBA1c Laboratory Tests Market Driven by Rise in Diabetic Population

The global HBA1c laboratory tests market is projected to expand at a significant pace over the coming years, driven by an increase in the prevalence of diabetes, rise in prescription rate of HBA1c tests... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.