We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBE SCIENTIFIC, LLC

Download Mobile App




Wearable Sensing Patch Enables Rapid Quantitative Analysis of Urea in Body Fluids

By LabMedica International staff writers
Posted on 24 Feb 2023

Urea, which is excreted in sweat, urine, saliva and blood, is a key indicator of renal function in clinical diagnosis. More...

Effective determination of urea levels can enable early detection of diseases. There has been growing focus on wearable fluorescence-based sensors, although traditional fluorescent hydrogels are excited by short wavelengths, hampering the detection of biological samples. Now, researchers have developed a wearable sensing patch that enables the rapid quantitative analysis of urea.

Spontaneous and background fluorescence can interfere with the detection of biological samples. Upconversion nanoparticles (UCNPs), which can eliminate the self-fluorescence and background interference of biological samples, are an effective strategy for detecting human biomarkers with high sensitivity. Researchers from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (Beijing, China) have developed a polyacrylamide (PAM) hydrogel sensor based on an upconversion optical probe, which was composed of UCNPs and p-dimethylamino-cinnamaldehyde (p-DMAC). As a result of the internal filtration effect, the red product produced by the reaction of urea and p-DMAC quenched the green fluorescence of the UCNPs and caused the upconversion fluorescence to change from yellow to red, thus realizing the fluorescence detection of urea.

Based on this, the researchers fabricated a flexible wearable sensor by combining PAM hydrogel and a portable sensor platform built using 3D printing technology. The researchers found the limits of detection of the self-designed upconversion fluorescent probe and the hydrogel sensor to be just 1.4 μM and 30 μM, respectively, which was much lower than the urea content in sweat, implying higher sensitivity. The sensor patch design paves the way for a convenient approach to accurately detect biomarkers in body fluids and for development into a device that could provide disease warning and clinical diagnosis, according to the researchers.

Related Links:
Chinese Academy of Sciences


New
Gold Member
Serological Pipets
INTEGRA Serological Pipets
Serological Pipet Controller
PIPETBOY GENIUS
New
Autoimmune Disease Diagnostic
Chorus ds-DNA-G
New
Gold Member
Blood Gas Analyzer
Stat Profile pHOx
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.