We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

DIASORIN

DiaSorin develops, produces and commercializes diagnostic tests for a wide range of clinical areas. The company’s tes... read more Featured Products: More products

Download Mobile App




Vitamin D Deficiency Associated with Impaired Muscle Strength

By LabMedica International staff writers
Posted on 05 Nov 2019
Print article
Image: The LIAISON 25 OH Vitamin D TOTAL Assay is a fully automated assay measuring both D2 and D3 for a total result (Photo courtesy of Diasorin).
Image: The LIAISON 25 OH Vitamin D TOTAL Assay is a fully automated assay measuring both D2 and D3 for a total result (Photo courtesy of Diasorin).
Maintaining muscle mass and function throughout life is a crucial component of successful ageing. The progressive loss of skeletal muscle mass, accompanied by a loss of muscle strength or performance, in aging, is a feature of primary sarcopenia.

Globally, vitamin D deficiency is widespread particularly in older populations and optimizing vitamin D status may be a practical and cost-effective approach that supports skeletal muscle function. An important consideration is if older adults with vitamin D deficiency have impaired muscle function and, if so, would raising 25(OH)D status or reversing deficiency improve or preserve function.

Clinical medicine scientists at Trinity College Dublin (Dublin, Ireland) analyzed data from 4,157 community-dwelling adults aged 60 years and over, from the English Longitudinal Study of Aging (ELSA). Two validated measures of muscle function were assessed, namely hand grip strength and the Short Physical Performance Battery (SPPB). Serum vitamin D was measured [25-hydroxyvitamin D] with a concentration <30 nmol/L classed as vitamin D deficient, the cut-off known to be associated with bone disease.

Serum 25(OH)D was assessed from fasting blood sample and analyzed using Diasorin Liaison 25-hydroxyvitamin D immunoassay (Diasorin, Saluggia, Italy). All assays were performed in duplicate, the CV values ranged from 8.7% to 9.4%. All blood sampling occurred from January 2012 to July 2013. Vitamin D status was classified with deficiency compatible with bone health risk defined as 25(OH)D <30 nmol/L, and insufficiency as <50 nmol/L. Season was categorized using the extended vitamin D calendar for summer (April–September) and winter (October–March).

The team reported that the prevalence of muscle weakness was twice as high among older adults with vitamin D deficiency (40.4%) compared with vitamin D adequacy (21.6%). Similarly, impaired 'muscle performance' was three times higher in older adults with vitamin D deficiency (25.2%) compared with vitamin D adequacy (7.9%). Based on more complex statistical analysis, the study showed that vitamin D deficiency significantly increased the likelihood of impaired muscle strength and performance.

Maria O'Sullivan, PhD, an Associate Professor and senior author of the study, said, “Our results show that vitamin D deficiency increased the likelihood of poor muscle function in older adults and confirms the protective effect of physical activity. Maintaining muscle function is incredibly important, and often overlooked, in promoting healthy ageing.” The study was published on October 15, 2019, in the journal Clinical Interventions in Aging.

Related Links:
Trinity College Dublin
Diasorin


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article

Channels

Molecular Diagnostics

view channel
Image: The study showed the blood-based cancer screening test detects 83% of people with colorectal cancer with specificity of 90% (Photo courtesy of Guardant Health)

Blood Test Shows 83% Accuracy for Detecting Colorectal Cancer

Colorectal cancer is the second biggest cause of cancer deaths among adults in the U.S., with forecasts suggesting 53,010 people might die from it in 2024. While fewer older adults are dying from this... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more

Microbiology

view channel
Image: The new platform is designed to perform blood-based diagnoses of nontuberculosis mycobacteria (Photo courtesy of 123RF)

New Blood Test Cuts Diagnosis Time for Nontuberculous Mycobacteria Infections from Months to Hours

Breathing in nontuberculous mycobacteria (NTM) is a common experience for many people. These bacteria are present in water systems, soil, and dust all over the world and usually don't cause any problems.... Read more

Industry

view channel
Image: These new assays are being developed for use on the recently introduced DxI 9000 Immunoassay Analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter and Fujirebio Expand Partnership on Neurodegenerative Disease Diagnostics

Beckman Coulter Diagnostics (Brea, CA, USA) and Fujirebio Diagnostics (Tokyo, Japan) have expanded their partnership focused on the development, manufacturing and clinical adoption of neurodegenerative... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.