We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Diagnostic Accuracy Demonstrated in Oral Glucose Tolerance Test

By LabMedica International staff writers
Posted on 02 Jan 2019
The incidence of overweight and obesity among children has increased dramatically in recent decades, with about one-third of children in the USA currently being either overweight or obese. More...
Being overweight in early childhood increases risk for later obesity.

During an oral glucose tolerance test (OGTT), morphological features of the glucose curve, monophasic curve, glucose peak more than 30 minutes and 1‐hr glucose of equal to or greater than 155mg/dL, maybe associated with higher prediabetes risk, but their reproducibility and predictive ability in adolescents with obesity are unknown.

Scientists working with the Essentia Health-Duluth Clinic (Duluth, MN, USA) analyzed data from adolescent girls with obesity but without diabetes who underwent a multiple-sample OGTT at baseline (n = 93), six weeks (n = 83) and one year (n = 72) as part of a randomized controlled trial. They obtained plasma samples to measure glucose and insulin concentrations at 0, 30, 60, 90 and 120 minutes. Prediabetes was defined as a fasting glucose level between 100mg/dL and 126 mg/dL and/or a 2-hour glucose level between 140 mg/dL and 200 mg/dL. They compared short-term reproducibility (baseline to six weeks) and predictive ability for prediabetes (baseline to one year) for each feature using standard fasting and 2-hour OGTT criteria.

The percentage of youths with prediabetes (12%) was the same at baseline and at six weeks. Six girls diagnosed with prediabetes at baseline were reclassified as having normal glucose tolerance at six weeks, whereas eight girls with normal glucose tolerance at baseline were reclassified as having prediabetes at six weeks. Among 72 girls examined at 1-year follow-up, 11 had prediabetes at baseline and seven had prediabetes at one year. Compared with OGTT criteria, ROC-AUC was lower for monophasic curve variable (0.42), but not different for 1-hour glucose (0.67), glucose peak at 30 minutes (0.68) or a combination of 1-hour glucose and glucose peak variables (0.77).

Kannan Kasturi, MD, a pediatric endocrinologist and lead author of the study, said, “In up to 25% of youth who develop type 2 diabetes, the fasting, two-hour glucose concentration of HbA1c may be below the prediabetes diagnostic thresholds two years prior to diabetes diagnosis. The need to improve risk stratification is further amplified in adolescent girls who have high rates of developing type 2 diabetes and may benefit from targeted, intensive intervention programs.” The study was published on December 6, 2018, in the journal Pediatric Diabetes.

Related Links:
Essentia Health-Duluth Clinic


Gold Member
Troponin T QC
Troponin T Quality Control
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
DNA/RNA Extraction/Purification Kit
Nucleic Acid Extraction or Purification Kit
New
PlGF Test
Quidel Triage PlGF Test
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: An “evolutionary” approach to treating metastatic breast cancer could allow therapy choices to be adapted as patients’ cancer changes (Photo courtesy of 123RF)

Evolutionary Clinical Trial to Identify Novel Biomarker-Driven Therapies for Metastatic Breast Cancer

Metastatic breast cancer, which occurs when cancer spreads from the breast to other parts of the body, is one of the most difficult cancers to treat. Nearly 90% of patients with metastatic cancer will... Read more

Pathology

view channel
Image: A real-time trial has shown that AI could speed cancer care (Photo courtesy of Campanella, et al., Nature Medicine)

AI Accurately Predicts Genetic Mutations from Routine Pathology Slides for Faster Cancer Care

Current cancer treatment decisions are often guided by genetic testing, which can be expensive, time-consuming, and not always available at leading hospitals. For patients with lung adenocarcinoma, a critical... Read more

Technology

view channel
Image: Researchers Dr. Lee Eun Sook and Dr. Lee Jinhyung examine the imprinting equipment used for nanodisk synthesis (Photo courtesy of KRISS)

Multifunctional Nanomaterial Simultaneously Performs Cancer Diagnosis, Treatment, and Immune Activation

Cancer treatments, including surgery, radiation therapy, and chemotherapy, have significant limitations. These treatments not only target cancerous areas but also damage healthy tissues, causing side effects... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.