We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Biomarker Assay Recommended for Heart Failure Diagnosis

By LabMedica International staff writers
Posted on 02 Apr 2018
Print article
Image: The cobas e 601 immunology analyzer (Photo courtesy of Roche Diagnostics).
Image: The cobas e 601 immunology analyzer (Photo courtesy of Roche Diagnostics).
The value of a biomarker to accurately diagnose or rule out acute heart failure in patients seen for shortness of breath at hospital emergency departments has been validated.

N-terminal pro-brain natriuretic peptide (NT-proBNP) and a related protein called (B-type natriuretic peptide (BNP) are both produced when the cardiac muscle is under stress.

A multi-institutional team led by those at the Massachusetts General Hospital (Boston, MA, USA) enrolled 1,461 adult patients who had come to hospital emergency departments (ED) with shortness of breath or other breathing difficulties. The study was conducted in 2015 and 2016 at 19 sites in the USA and Canada. Blood samples to be measured for NT-proBNP levels were taken upon study enrollment, and determination of the presence of acute heart failure. A cobas e 601 analyzer was used for all NT-proBNP measurements. Primary endpoints were positive predictive values of age-stratified cutoffs (450, 900, and 1,800 pg/mL) for diagnosis of acute heart failure (HF) and negative predictive value of the rule-out cutoff to exclude acute HF. Secondary endpoints included sensitivity, specificity, and positive (+) and negative (−) likelihood ratios (LRs) for acute HF.

The scientists reported that of 1,461 subjects, 277 (19%) were adjudicated as having acute HF. The median NT-proBNP concentration of patients with acute HF (2,844 pg/mL; interquartile range: 1,247 to 5,976 pg/mL) was substantially higher than those without acute HF (98 pg/mL; interquartile range: 35 to 369 pg/mL). The area under the receiver-operating characteristic curve for diagnosis of acute HF was 0.91. Sensitivity for age-stratified cutoffs of 450, 900, and 1,800 pg/mL was 85.7%, 79.3%, and 75.9%, respectively; specificity was 93.9%, 84.0%, and 75.0%, respectively. Positive predictive values were 53.6%, 58.4%, and 62.0%, respectively. The sensitivity and negative predictive value for the rule-out cutoff of 300 pg/mL were 93.9% and 98.0%, respectively; LR− was 0.09.

The authors concluded that in acutely dyspneic patients seen in the ED setting, age-stratified NT-proBNP cut-off points may aid in the diagnosis of acute HF. An NT-proBNP <300 pg/ml strongly excludes the presence of acute HF. James Januzzi Jr., MD, a Professor of Medicine and lead author of the study, said, “We found no specific population in which the test did not perform well, and what was most striking to me - as someone who has been working with NT-proBNP since the early 2000s - was how consistent these results were with those of prior studies. Given the changes in the types of patients with heart failure we see today, it's quite remarkable how reliable this test is.” The study was published on March 20, 2018, in the Journal of the American College of Cardiology.

Related Links:
Massachusetts General Hospital

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
POCT Fluorescent Immunoassay Analyzer
FIA Go
Gold Member
Real-time PCR System
GentierX3 Series

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.