We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Marker for Iron Availability Derived From Blood Test

By LabMedica International staff writers
Posted on 18 Jul 2011
Low hemoglobin density (LHD%) is a new parameter provided by an autoanalyzer that can be derived from the mean cell hemoglobin concentration. More...


The diagnosis of iron deficiency or functional iron deficiency is particularly challenging in patients with acute or chronic inflammatory conditions because most of the biochemical markers for iron metabolism are affected by acute phase reaction.

Scientists at the Hospital Galdakao – Usansolo, (Galdakao, Spain), used the program of the LH 780 analyzer to study 110 patients with iron deficiency (IDA); 65 with chronic kidney disease (CKD), and 85 with anemia of chronic disease (ACD), 24 of whom were iron deficient and 61 were iron sufficient and 90 healthy subjects. A total of 350 peripheral blood samples were analyzed during the 2-month period from March 2010 to April 2010.

Low hemoglobin density values showed no statistical difference in patients with IDA and patients with ACD accompanied with IDA. The LHD% values in these patients were significantly different compared with the iron-sufficient patients with ACD. Receiver operating characteristic (ROC) curve analysis for LHD% in the detection of iron deficiency showed the following: area under curve 0.903; cut off 5.5%, with a sensitivity of 88.6%, and a specificity of 76.9%.

The author concluded that in the present study the parameter, LHD% is useful for diagnosing iron deficiency and is a reliable parameter for recognizing subsets of anemic patients and therefore improving the diagnosis and management of anemia. The LHD% analysis can be performed simultaneously in the course of routine blood counts, with no incremental costs and no additional blood sampling. In conjunction with standard blood cell counts and iron parameters, LHD% could enable the diagnosis to be made rapid and accurately, when using the LH 780 analyzer (Beckman Coulter Inc., Miami, FL, USA). The study was published on July 4, 2011, in the International Journal of Laboratory Hematology.

Related Links:

Hospital Galdakao – Usansolo
Beckman Coulter Inc.



Gold Member
Quantitative POC Immunoassay Analyzer
EASY READER+
Serological Pipet Controller
PIPETBOY GENIUS
New
Automated PCR Setup
ESTREAM
New
Clostridium Difficile Toxin A+B Combo Card Test
CerTest Clostridium Difficile Toxin A+B
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.