We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Apolipoprotein B Singled Out as Heart Attack Risk Predictor

By LabMedica International staff writers
Posted on 09 Dec 2021
Print article
Image: Apolipoprotein B–containing lipoproteins are associated with risk of myocardial infarction in individuals with and without atherosclerosis (Photo courtesy of the Cardiovascular Research Foundation)
Image: Apolipoprotein B–containing lipoproteins are associated with risk of myocardial infarction in individuals with and without atherosclerosis (Photo courtesy of the Cardiovascular Research Foundation)
The selection of risk factors is based on what makes a highly significant independent contribution to predicting risk. Age, sex, smoking, systolic blood pressure and total cholesterol are well known to be important. Also, diabetes and left ventricular hypertrophy increase risk as does a previous stroke or heart attack.

Apolipoprotein B (Apo B) is a major protein component of low-density lipoprotein (LDL) comprising >90% of the LDL proteins and constituting 20-25% of the total weight of LDL. Apo B exists in two forms. Apo B-100, the most abundant form of Apo B, is found in lipoproteins synthesized by the liver including LDL, VLDL, and IDL. Lipid management typically focuses on levels of low-density lipoprotein cholesterol (LDL-C) and, to a lesser extent, triglycerides (TG).

Cardiologists at the Brigham and Women’s Hospital (Boston, MA, USA) and their colleagues carried out prospective cohort analysis included individuals from the population-based UK Biobank and from two large international clinical trials. The median (IQR) follow-up was 11.1 (10.4-11.8) years in UK Biobank and 2.5 (2.0-4.7) years in the clinical trials.

Two populations were studied in this analysis: 389,529 individuals in the primary prevention group who were not taking lipid-lowering therapy and 40,430 patients with established atherosclerosis who were receiving statin treatment. Of the 389,529 individuals in the primary prevention group, 224,097 (58%) were female, and the median (IQR) age was 56.0 (49.5-62.5) years. Of the 40,430 patients with established atherosclerosis, 9647 (24%) were female, and the median (IQR) age was 63 (56.2-69.0) years. The scientist determined whether common measures of cholesterol concentration, TG concentration, or their ratio are associated with cardiovascular risk beyond the number of apolipoprotein B (apoB)–containing lipoproteins.

The investigators reported that in the primary prevention cohort, apoB, non–HDL-C, and TG each individually were associated with incident myocardial infarction (MI). However, when assessed together, only apoB was associated (adjusted hazard ratio [aHR] per 1 SD, 1.27; P < .001). Similarly, only apoB was associated with MI in the secondary prevention cohort. Adjusting for apoB, there was no association between the ratio of TG to LDL-C (a surrogate for the ratio of TG-rich lipoproteins to LDL) and risk of MI, implying that for a given concentration of apoB-containing lipoproteins, the relative proportions of particle subpopulations may no longer be a predictor of risk.

Nicholas Marston, MD, MPH, a Cardiologist and lead author of the study said, “We looked at apolipoprotein B, non-HDL cholesterol, and triglycerides, and all three are predictive of risk when you look at them independently and without adjustment. Even when you adjust for clinical factors, each were predictive of MI, which is the endpoint of interest in this study. However, when you also adjusted for the other lipid parameters, apolipoprotein B was the only one that remained significant.”

The authors concluded that in the cohort study, risk of MI was best captured by the number of apoB-containing lipoproteins, independent from lipid content (cholesterol or TG) or type of lipoprotein (LDL or TG-rich). This suggests that apoB may be the primary driver of atherosclerosis and that lowering the concentration of all apoB-containing lipoproteins should be the focus of therapeutic strategies. The study was published on November 13, 2021 in the journal JAMA Cardiology.

Related Links:
Brigham and Women’s Hospital

Automated ELISA-IFA-BLOT Processor AP 22
Gold Supplier
Influenza Type A & B Test
Influenza A+B DUO
Gold Supplier
SARS-CoV-2 Antigen Rapid Test
RapiSafe SARS-CoV-2 Antigen Rapid Test (Professional use)
High-Throughput Cellular Screening System

Print article


Molecular Diagnostics

view channel
Image: A new method reliably detects protein changes in blood that are typical of Parkinson`s disease (Photo courtesy of Pexels)

First-Ever Blood Test Detects Parkinson’s Disease

Until now, the diagnosis of Parkinson's disease has been based primarily on typical movement disorders such as muscle stiffness, slower movements and shaking. However, the disease starts up to 20 years... Read more


view channel
Image: Fujirebio has acquired ADx NeuroSciences for 40 million Euros (Photo courtesy of Pexels)

Fujirebio Acquires ADx NeuroSciences to Speed Development of Neurodegenerative Diseases Diagnostic Tests

Fujirebio Holdings, Inc. (Tokyo, Japan) has announced the acquisition of ADx NeuroSciences (Gent, Belgium) for EUR 40 million in a deal that is expected to close in July 2022, pending the satisfaction... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.