We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics- Hematology Division

Download Mobile App





T-Cell Tests Unreliable in Establishing Previous COVID-19 Infection, Finds New Study

By LabMedica International staff writers
Posted on 05 Oct 2021
Print article
Illustration
Illustration

T-cell tests can be unreliable in establishing previous COVID-19 infection, according to the findings of a new study.

In the study, scientists at Uppsala University (Uppsala, Sweden) and Karolinska Institutet (Stockholm, Sweden) jointly analyzed if T-cell tests can be used to determine whether people have had COVID-19. By analyzing the T cells’ responses to varying peptide compositions, the researchers were able to see that different peptide pools produced divergent responses, and that a risk of false-positive responses existed. In the scientists’ view, this risk is due to the fact that the peptides can give rise to responses from memory T cells that originated in some way other than through a SARS-CoV-2 infection – from a common cold, for example.

When the scientists attempted to avoid using peptides that might give rise to these cross-reactive responses, there was an increase in the specificity of the test – that is, its ability to establish genuine negative responses – but its sensitivity (ability to detect a true positive response) simultaneously declined at the time of sampling and analysis, which was 4-5 months post COVID-19.

“In the follow-up study, the participants with a relatively mild initial disease clearly didn’t always have measurable SARS-CoV-2 specific T cells in blood. But among those with a disease that’s initially more serious, there were more who had measurable SARS-CoV-2-specific T cells in blood over time,” said Sara Mangsbo, a research scientist in immuno-oncology at Uppsala University. “The correlation we found between the severity of the disease and a measurable, established memory response in the blood isn’t entirely unexpected; but it’s still important to establish, since the use of T-cell tests has been a matter of public discussion for numerous reasons."

“It’s also important to say that the subjects’ blood doesn’t always contain the memory T cells after the disease is over. Still, cells in tissues – which aren’t measurable by means of a blood-based test for T cells – may have a part to play in how ill people get during an infection,” said Charlotte Thålin, a specialist doctor and researcher responsible for the COMMUNITY study at Danderyd Hospital and Karolinska Institutet. “T-cell tests will continue to have an important part to play in research and studies, but probably a smaller one in diagnostics and at individual level for SARS-CoV-2 in particular.”

Related Links:
Uppsala University
Karolinska Institutet

Gold Supplier
Nucleic Acid Detection Kit For COVID-19 (PCR Fluorescence Probe)
Nucleic Acid Detection Kit For COVID-19 (PCR Fluorescence Probe)
New
GADAb ELISA Assay
KRONUS Glutamic Acid Decarboxylase Autoantibody (GADAb) ELISA Assay Kit
New
Cardiovascular Disease POC Analyzer
cobas h 232 POC System
New
Gold Supplier
Centrifuge
Multifuge X4 Pro Centrifuge Series

Print article

Channels

Molecular Diagnostics

view channel
Image: Absence of nuclear immunohistochemical staining of MSH2 protein (A) and presence of MLH1 protein (B) in urothelial cell carcinoma of the urinary bladder of a patient carrying a germline MSH2 mutation. Observe the nuclear staining in stromal cells as an internal control (Photo courtesy of Radboud University Nijmegen Medical Centre)

Simple Urine Test Detects Urothelial Cancers in Lynch Syndrome Patients

Lynch Syndrome (LS) is an inherited genetic disorder that carries a high risk of cancer. LS is caused by mutations affecting MLH1, MSH2, MSH6 or PMS2 genes. More than one in 300 people have LS but most... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test for screening, diagnosis and management of sickle cell disease and related hemoglobinopathies at the point of care (Photo courtesy of Hemex Health)

Point-of-Care Device Accurately Rapidly Diagnoses Sickle Cell Disease

Hemoglobinopathies are the most common autosomal hereditary disorders. Approximately 7% of the global population carries hemoglobin gene mutation including structural hemoglobin variants like sickle hemoglobin... Read more

Immunology

view channel
Image: The IMMULITE 2000 XPi Immunoassay System provides multiple tests on a single, easy-to-use analyzer, including the thyroid-stimulating immunoglobulin assay (Photo courtesy of Siemens Healthcare)

Immunoassays Evaluated for Thyroid-Stimulating Receptor Antibody in Graves’ Disease

Graves' disease (GD), also known as toxic diffuse goiter, is an autoimmune disease that affects the thyroid. It frequently results in and is the most common cause of hyperthyroidism and it also often results... Read more

Microbiology

view channel
Image: The sciREADER CL2 enables high quality digital colorimetric imaging of various support formats (Photo courtesy of SCIENION)

Multiplex Immunoassay Developed for Confirmation and Typing of HTLV Infections

Human T-Cell Lymphotropic Viruses (HTLV) type 1 and type 2 account for an estimated five to 10 million infections worldwide and are transmitted through breast feeding, sexual contacts and contaminated... Read more

Pathology

view channel
Illustration

AI Accurately Detects and Diagnoses Colorectal Cancer from Tissue Scans As Well or Better Than Pathologists

Artificial intelligence (A) can accurately detect and diagnose colorectal cancer from tissue scans as well or better than pathologists, according to a new study. The study, which was conducted by researchers... Read more

Technology

view channel
Image: PKeye Workflow Monitor System (Photo courtesy of PerkinElmer, Inc.)

PerkinElmer’s New Cloud-Based Platform Enables Laboratory Personnel to Remotely Manage Its Instruments in Real-Time

PerkinElmer, Inc. (Waltham, MA; USA) has launched its PKeye Workflow Monitor, a cloud-based platform enabling laboratory personnel to remotely manage and monitor their PerkinElmer instruments and workflows... Read more

Industry

view channel
Illustration

Global Point of Care Diagnostics Market to Top USD 35 Billion by 2027 Due to Rising Diabetic Cases

The global point of care diagnostics market is projected to grow at a CAGR of close to 6% from more than USD 23 billion in 2020 to over USD 35 billion by 2027, driven by an increase in the number of diabetic... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.