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Pathology

Image: Histopathology of (a) Usual-type high-grade urothelial carcinoma and (b) Positive E-cadherin expression in usual-type high-grade urothelial carcinoma. (Photo courtesy of Emory University School of Medicine)

Biomarker p-120 Catenin Distinguishes Conventional Urothelial Carcinoma from Variants

Plasmacytoid urothelial carcinoma (PC-UC) is an infrequent and clinically aggressive variant of urothelial carcinoma (UC). Initially, PC-UC was identified based on morphology as a potential mimicker of malignant plasma cell and lymphoid neoplasms and is characterized by loss of E-cadherin (E-Cad)–mediated intercellular adhesion. More...
24 Aug 2021
Image: Novel Blood-Based Stockholm3 (STHLM3) Test Bolsters MRI-Based Prostate Cancer Screening (Photo courtesy of Julie-Ann O`Reilly, PhD)

Novel Blood-Based Test Bolsters MRI-Based Prostate Cancer Screening

Prostate cancer does not usually cause any symptoms until the cancer has grown large enough to put pressure on the tube that carries urine from the bladder out of the penis (urethra). Symptoms of prostate cancer can include: needing to urinate more frequently, often during the night needing to rush to the toilet. More...
23 Aug 2021
Image: Histopathology shows extensive liver cell damage resulting from alcoholic hepatitis (Photo courtesy of The Johns Hopkins University)

Key Factors Signal Infection Risk in Alcoholic Hepatitis

Alcohol-associated hepatitis (AAH) is a severe form of liver injury with mortality as high as 30%-40% at 90 days. As a result of altered immune function in AAH, bacterial infections are common and are associated with poor outcomes. More...
17 Aug 2021
The QiaSymphony DSP DNA Midi kit (Photo courtesy of Qiagen)

Genomes of Advanced Neuroendocrine Neoplasms Unveil Subtypes

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and genetically heterogeneous malignancies, characterized by distinct prognoses based upon primary tumor localization, functionality, grade, proliferation index and diverse outcomes to treatment. More...
13 Aug 2021
A novel protein-based multitarget fecal immunochemical test (mFIT) for colorectal cancer (CRC) screening was superior to conventional FIT in detecting advanced neoplasia, particularly advanced adenomas (Photo courtesy of Mike Bassett)

Multitarget Fecal Immunochemical Test Validated for Colorectal Cancer

Colorectal cancer (CRC) starts in the colon or the rectum. These cancers can also be called colon cancer or rectal cancer, depending on where they start. Colon cancer and rectal cancer are often grouped together because they have many features in common. More...
08 Aug 2021
Photomicrograph shows brown-immunostained alpha-synuclein in Lewy bodies (large clumps) and Lewy neurites (thread-like structures) in the neocortical tissue of a person who died with Lewy body disease (Photo courtesy of Movalley)

CSF Conversion Assay Identifies Lewy Body Disease Cognitive Impairment

Lewy body dementia, also known as dementia with Lewy bodies, is the second most common type of progressive dementia after Alzheimer's disease. Protein deposits, called Lewy bodies, develop in nerve cells in the brain regions involved in thinking, memory and movement (motor control). More...
08 Aug 2021
Signatera assay used for the detection of molecular residual disease using personalized circulating tumor DNA assay in patients with colorectal cancer undergoing resection of metastases (Photo courtesy of Natera)

Minimal Residual Disease Test Predicts Oligometastatic CRC Patient Outcomes

Colorectal cancer (CRC) is the fourth most common cancer and the second-leading cause of cancer-related death in the USA. Approximately 15%-25% of patients present with metastatic disease upon diagnosis, and approximately 50% of patients with early-stage disease develop metastases. More...
06 Aug 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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