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Pathology

Image: Histopathology of dissected appendiceal tissue showing moderately differentiated neoplastic glands lined by cells with nuclear pleomorphism and hyperchromasia (Photo courtesy of Pacific Northwest University of Health Sciences).

Distinct Mutation Patterns Identified in Appendiceal Cancer

The incidence of appendiceal cancer (AC) is rising, particularly among individuals younger than 50 years (early-onset AC), with unexplained etiologies. The unique spectrum of somatic cancer gene variations among patients with early-onset AC is largely undetermined. More...
24 Dec 2020
Image: The CELLSEARCH Circulating Tumor Cell (CTC) Test is used for determining the prognosis of patients with metastatic breast, prostate and colorectal cancer (Photo courtesy of Menarini Silicon Biosystems).

Circulating Tumor Cell Dynamics Predicts Cancer Prognosis

Metastatic breast cancer, also called stage IV breast cancer, means the cancer has traveled through the bloodstream to create tumors in the liver, lungs, brain, bones and/or other parts of the body. Approximately 20% to 30% of women with early stage breast cancer go on to develop metastatic disease. More...
23 Dec 2020
Image: The UF-500i fully automated urine particle analyzer (Photo courtesy of Sysmex Corporation).

Flow Cytometry Employed in Diagnosing Male Urethritis

According to the established guidelines, diagnosis of non-gonococcal urethritis should be confirmed by demonstrating polymorphonuclear leukocytes from the anterior urethra using a Gram-stained (GSS) or methylene blue-stained urethral smear. More...
17 Dec 2020
Image: nCounter NanoString: Gene expression profiling platform (Photo courtesy of Institute Pasteur).

Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression

Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...
16 Dec 2020
Image: Triple fecal immunochemical testing (FIT) surpasses single sigmoidoscopy in colorectal cancer (CRC) screening (Photo courtesy of Pinnacle Biolabs).

Triple FIT Surpasses Single Sigmoidoscopy in CRC Screening

Colorectal cancer (CRC) almost always develops from precancerous polyps (abnormal growths) in the colon or rectum. Screening tests can find precancerous polyps, so that they can be removed before they turn into cancer. Screening tests can also find colorectal cancer early, when treatment works best. More...
10 Dec 2020
Image: Histopathology of a cirrhotic liver.  High-density lipoprotein cholesterol predicts survival in cirrhotic patients with acute gastrointestinal bleeding (Photo courtesy of Loyola University Chicago).

HDL-Cholesterol Predicts Survival in Cirrhotic Patients with Gastrointestinal Bleeding

Liver cirrhosis is an important cause of morbidity and mortality as a consequence of continuous liver injuries. Acute gastrointestinal bleeding is a serious complication and critical clinical event in cirrhotic patients. Hepatitis B virus (HBV) is the leading cause of liver cirrhosis in China. More...
10 Dec 2020
Image: Appearance of a `false brush border` of Brachyspira pilosicoli cells attached by one cell end to the luminal surface of human colonic enterocytes in a patient diagnosed with human intestinal spirochetosis (Photo courtesy of David J. Hampson, PhD, DSc).

Specific Gut Bacterium Linked to Irritable Bowel Syndrome

The incidence of Irritable Bowel Syndrome (IBS) steeply increases following a gastroenteritis episode, suggesting a possible causative role for microbial perturbation. Gut microbiota composition studies overwhelmingly rely on fecal material. More...
08 Dec 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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