We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Fluorescence Microscopy Combined with AI Enables Detection of Tumors at Early Stage

By LabMedica International staff writers
Posted on 18 Dec 2023
Print article
Image: The new method and use of AI could improve tumor diagnosis (Photo courtesy of 123RF)
Image: The new method and use of AI could improve tumor diagnosis (Photo courtesy of 123RF)

Detecting cancer in the body or monitoring it during therapy is typically a time-consuming process, often conducted in later phases when signs become obvious. Researchers engaged in cancer research are continuously seeking reliable and sensitive techniques to detect a developing tumor at a very early stage and to closely monitor the success or failure of cancer therapy. Therefore, a breakthrough in early cancer diagnosis is a significant advancement. Researchers have now achieved a breakthrough with the development of a test for early diagnosis of cancer.

Researchers at the Paul Scherrer Institute (Würenlingen, Switzerland) have demonstrated that changes in the organization of the cell nucleus of certain blood cells can reliably indicate the presence of a tumor in the body. Using fluorescence microscopy, the team examined the chromatin of these blood cells – DNA packaged into a complex structure. They analyzed about 200 different characteristics, including the external texture, the packing density, and the contrast of the chromatin in lymphocytes or monocytes. They input microscope images from healthy and sick test participants into an artificial intelligence (AI) system and employed “supervised learning” to teach the software known differences.

In the subsequent “deep learning” phase, the algorithm automatically identified differences between “healthy” and “sick” cells that are not discernible to the human eye. This technique enabled the scientists to distinguish between healthy individuals and those with cancer with approximately 85% accuracy. They were also able to correctly identify the type of tumor disease – melanoma, glioma, or head and neck tumor. This new technique, based on blood cell chromatin, is potentially applicable to various cancer types and not just limited to follow-up of proton therapy. It could also be relevant to other forms of therapy, including radiation therapy, chemotherapy, and surgery, although further research is needed to confirm these applications.

“This is the first time anyone, worldwide, has achieved this,” said G.V. Shivashankar, head of PSI‘s Laboratory for Nanoscale Biology who led the research team.

Related Links:
Paul Scherrer Institute

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Reagent Reservoirs
Reagent Reservoirs

Print article


Clinical Chemistry

view channel
Image: The new versatile assay has the ability to measure both total and bioavailable cortisol from serum (Photo courtesy of Aarhus University)

Highly Reliable Cell-Based Assay Enables Accurate Diagnosis of Endocrine Diseases

The conventional methods for measuring free cortisol, the body's stress hormone, from blood or saliva are quite demanding and require sample processing. The most common method, therefore, involves collecting... Read more

Molecular Diagnostics

view channel
Image: The simple blood test can measure changes in cellular metabolism arising from pancreatic cancer (Photo courtesy of Metabolomycs)

Groundbreaking Blood Test Offers Early Pancreatic Cancer Diagnosis

Pancreatic cancer ranks as the third leading cause of cancer-related deaths, primarily due to its late detection. Early discovery of the disease, while it's still treatable, could significantly impact... Read more


view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more


view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.