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Immunology

Image: Orientia tsutsugamushi present in the liquid scraped from the abdominal wall of an infected mouse. The abdominal walls of the infected mouse were fixed and stained with Giemsa stain and presence of O. tsutsugamushi particles (purple particles) detected by light microscopy (Photo courtesy of University of Illinois, Urbana-Champaign).

Scrub Typhus Enzyme Linked Immunoassay Evaluated for Accuracy

Scrub typhus is a rickettsial infection caused by a mite-borne bacterium, Orientia tsutsugamushi. It is primarily transmitted to humans through bites of infected trombiculid mite larvae, also known as chiggers. More...
28 Dec 2020
Image: The Alinity i is a compact, immunoassay system that can reliably be used to diagnose infectious diseases (Photo courtesy of Abbott Laboratories).

Newly Developed Immunoassay Evaluated for Infectious Diseases

Although a diagnosis of infectious diseases is essential for timely treatment, the performance of diagnostic tests has been hardly evaluated due to variable results that are influenced by multiple factors in different conditions. More...
23 Dec 2020
Image: Schematic illustration of the immuno‐infrared sensor. Using oligoclonal capture antibodies, all TDP‐43 isoforms are extracted out of CSF (Photo courtesy of Ruhr University Bochum).

Novel Biomarker Candidate for Amyotrophic Lateral Sclerosis Explored

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease causing a rapid loss of motor function, which usually results in a serious condition with early death within a few years. So far, early and precise diagnosis of the disease has been difficult. More...
23 Dec 2020
Image: BD enzyme-linked immunosorbent assays for natural C5b-9 in serum, plasma, and other biological samples (Photo courtesy of BD Biosciences).

Elevated Soluble C5b9 Biomarker Found in SARS-Cov-2 Infected Children

Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have mild or minimal disease, with a small proportion developing severe disease or multisystem inflammatory syndrome in children (MIS-C). More...
21 Dec 2020
Image: nCounter NanoString: Gene expression profiling platform (Photo courtesy of Institute Pasteur).

Gene Expression Signature Traces Nonalcoholic Fatty Liver Disease Progression

Nonalcoholic fatty liver disease (NAFLD) is a common condition marked by the accumulation of triglycerides and other lipids in the liver and is associated with metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia. More...
16 Dec 2020
Image: The GSP instrument is a high throughput batch analyzer intended for quantitative or qualitative measurement of neonatal screening samples on 96-well microplates (Photo courtesy of PerkinElmer).

Biomarker Evaluated for Early Detection of Congenital Heart Disease

Congenital heart disease (CHD) is the most common congenital malformation in humans worldwide. Circulating cardiovascular biomarkers could potentially improve the early detection of CHD, even in asymptomatic newborns. More...
16 Dec 2020
Image: Rheumatoid arthritis (RA)‐derived neutrophils exhibited increased spontaneous NETosis and increased NETotic response to tumor necrosis factor (TNF)‐α. Neutrophils were isolated from patients with RA and healthy controls (HC) (Photo courtesy of Central South University).

Anti‐Citrullinated Antibodies Associated with NET Formation in Rheumatoid Arthritis

Several cell types can form extracellular traps as a primary immune response when pathogens invade the body or other inflammatory stimuli. These cell types include neutrophils, monocytes, eosinophils, and mast cells. The mechanism by which neutrophil extracellular traps (NETs) are formed is known as NETosis. More...
14 Dec 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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