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Immunology

Image: The BD FACSCalibur fluorescent activated cell sorter platform allows users to perform both cell analysis and cell sorting in a single benchtop system (Photo courtesy of BD Biosciences).

sTNFR2 Revealed as a Novel Diagnostic Biomarker for Acute ATL

Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell neoplasm associated with human T-cell leukemia virus type 1 (HTLV-1). Although only about 5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. Soluble tumor necrosis factor 2 (sTNFR2) is a novel and promising diagnostic biomarker for acute ATL. More...
07 Apr 2020
Image: Ultra-fast Cycling for Multiplexed Cellular Fluorescence Imaging (Photo courtesy of Massachusetts General Hospital Research Institute).

Ultra-Fast Cycling for Multiplexed Cellular Fluorescence Imaging

In the treatment of tumors, microenvironment plays an important role. It often contains immune cells that are so changed that they promote tumor growth. Until now, analyses of these dynamic changes with conventional biopsies and tissue sections could take days to weeks, or not occur at all prior to treatment. More...
07 Apr 2020
Image: The Oxford Nanopore MinION device (Photo courtesy of Oxford Nanopore Technologies).

Deep Throat SARS-CoV-2 Viral Load Ascertained in Saliva Samples

Posterior oropharyngeal saliva samples are a non-invasive specimen more acceptable to patients and health-care workers. Unlike severe acute respiratory syndrome, patients with COVID-19 had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. More...
06 Apr 2020
Image: Photomicrograph of normal plasma cells from a bone marrow aspirate (Photo courtesy of Peter Anderson).

Molecule in Lymphatic System Implicated in Autoimmune Diseases

A healthy immune system defends the body against diseases and infection. When someone has an autoimmune disease, the immune system malfunctions and the body mistakenly attacks healthy cells, tissues and organs. Rheumatoid arthritis, lupus and scleroderma are examples of autoimmune diseases. More...
02 Apr 2020
Image: Factors associated with acute respiratory distress syndrome (ARDS) In COVID-19 identified (Photo courtesy of the Brian Orelli, PhD).

Factors Associated with ARDS in COVID-19 Identified

 Patients with COVID-19 present primarily with fever, myalgia or fatigue, and dry cough. Although most patients are thought to have a favorable prognosis, older patients and those with chronic underlying conditions may have worse outcomes. More...
30 Mar 2020
Image: Transmission electron micrograph of an isolate from a case of COVID-19, caused by the coronavirus SARS-CoV-2. The spherical viral particles, colorized blue, contain cross-sections through the viral genome, seen as black dots (Photo courtesy of Hannah A Bullock and Azaibi Tamin).

SARS-Cov-2 Specific Antibody Responses in COVID-19 Patients

 The rapid identification of the etiology and the sharing of the genetic sequence of the virus, followed by international collaborative efforts initiated due to the emergence of SARS-CoV-2 have led to the rapid availability of real-time PCR diagnostic assays that support the case ascertainment and tracking of the outbreak. More...
30 Mar 2020
Image: Sacroiliac joint biopsy specimen of a 29 year old male patient with ankylosing spondylitis. The biopsy specimen shows a subchondral cellular infiltrate partly invading the cartilage. Fibroblasts and activated lymphocytes are seen in the infiltrate. In between are areas of calcification and bone formation (Photo courtesy of Professor J. Braun).

Fibrinogen-Albumin Ratio Correlated to Ankylosing Spondylitis Disease Activity

 Ankylosing spondylitis (AS) is a systematic inflammatory autoimmune disease that primarily involves the spine and sacroiliac joints. Typically the joints where the spine joins the pelvis are also affected and occasionally other joints such as the shoulders or hips are involved. Back pain is a characteristic symptom of AS, and it often comes and goes. More...
23 Mar 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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