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Hematology

Image: FoundationOne Heme next-generation sequencing test can be used to assess routine cancer specimens for all genes that are currently known to be somatically altered and unambiguous drivers of oncogenesis in hematologic malignancies and sarcomas (Photo courtesy of Foundation Medicine)

Germline Genetic Testing Assesses Inherited Risk for Myeloid Malignancies

 Inherited risk for hematologic malignancies was historically thought to be relatively rare; however, the increased use of next-generation sequencing has identified more patients with germline genetic mutations that are known to increase cancer risk. More...
26 Dec 2019
Image: The LH 750 hematology analyzer is equipped with advanced technologies with nucleated red blood cell (NRBC) enumeration and random access capabilities (Photo courtesy of Fameco Medical)

Hepatic Dysfunction and Coagulopathy Quantified in Fatal Dengue Fever

 Dengue fever (DF) is currently one of the most severe public health problems. Each year, an estimated 390 million dengue infections occur around the world. Clinical presentations of dengue are diverse and non-specific, often with unpredictable clinical progression and outcome. More...
24 Dec 2019
Image: Bone marrow film from a patient with myelodysplastic syndrome demonstrates small hypolobated megakaryocytes that are typical of the syndrome with isolated del(5q) (Photo courtesy of John P. Hunt, MD)

Distinct Myelodysplastic Syndrome Subtypes Identified by Genomic, Transcriptomic Analysis

 Myelodysplastic syndrome is a premalignant disease that affects myeloid cell. It is a precursor to acute myeloid leukemia, an aggressive blood cancer caused by the accumulation of immature blood cells. More...
23 Dec 2019
Image: Among critically ill pediatric patients, the use of fresh red blood cells did not reduce the incidence of new or progressive multiple organ dysfunction syndrome (including mortality),  compared with standard-issue red blood cells (Photo courtesy of The Children`s Hospital Westmead)

Fresh Red Blood Cells Transfusions No Better Than Older Ones

 Red blood-cell transfusions are commonly administered in critically ill children who have illnesses that increase the need for transfusion, such as trauma, cancer chemotherapy, major surgery with significant intraoperative bleeding, and conditions such as sickle cell disease and thalassemia. More...
23 Dec 2019
Image: Bone marrow smear from a patient with mixed phenotype acute leukemia. The marrow aspirate smear has 71% blasts by differential count, with a similar dimorphic morphology as in the peripheral blood with numerous blasts with a dimorphic morphology (Photo courtesy of Elizabeth Courville, MD).

Single-Cell Analysis Uncovers Regulatory Program in Rare Leukemia

 Identifying the causes of human diseases requires deconvolution of abnormal molecular phenotypes spanning DNA accessibility, gene expression and protein abundance. Mixed-phenotype acute leukemia exhibits features of both acute myeloid leukemia and acute lymphoblastic leukemia and, as such, is marked by features of multiple hematopoietic lineages. More...
18 Dec 2019
Image: The cobas c 502 is a medium throughput clinical chemistry module that performs photometric assay tests for a wide range of analytes (Photo courtesy of Roche).

Autoimmunity Markers Prevalence Assessed in Immune Thrombocytopenia

 Immune thrombocytopenia (ITP) is an acquired autoimmune disorder resulting from decreased platelet production and increased platelet destruction. Platelet autoantibodies in ITP lead to both acceleration of platelet destruction in the spleen and inhibition of platelet production by bone marrow megakaryocytes. More...
17 Dec 2019
Image: Peripheral blood smear showing chronic lymphocytic leukemia (CLL). A large lymphocyte (arrow) has a notched nucleus and demonstrates the variable appearance of some of the lymphocytes in CLL (Photo courtesy of Peter Maslak)

TP53 Gene Promoter Methylation Impacts Chronic Lymphocytic Leukemia

 Chronic lymphocytic leukemia (CLL) is a clonal disorder that results in the accumulation of morphologically mature-looking and immunologically incompetent lymphoid cells in the bone marrow, peripheral blood, and lymphatic tissues. More...
11 Dec 2019
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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