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Molecular Diagnostics

Image: The Kalazar Detect Rapid Test for Visceral Leishmaniasis (VL) is a rapid immunochromatographic strip assay for the qualitative detection of antibodies to L. donovani complex in human serum to aid in the presumptive diagnosis of VL (Photo courtesy of InBios).

LAMP Assay Validated for Visceral Leishmaniasis

Visceral leishmaniasis (VL) is one of the most neglected infectious diseases with an annual incidence of 50,000 to 90,000 new cases worldwide. Cases of VL are characterized by irregular bouts of fever, weight loss, hepatosplenomegaly, hypergammaglobulinemia, pancytopenia and anaemia. More...
03 Dec 2018
Image: An illustration showing detection of a single influenza virion using a solid-state nanopore (Photo courtesy of Osaka University).

Nanopore Method Detects Single Influenza Virus at Single Particle Level

A team of Japanese researchers has introduced a novel sensor concept capable of discriminating various types of influenza virus in a label-free fashion by their distinct particle properties. More...
03 Dec 2018
Image: The nCounter platform provides a simple and cost effective solution for multiplex analysis of up to 800 RNA, DNA, or protein targets from diverse samples (Photo courtesy of NanoString).

Highly Multiplexed Broad Pathogen Assay Detects Infectious Diseases

Identifying the causative agent in an acute febrile illness can be challenging diagnostically, especially when organisms in a particular region have overlapping clinical presentation or when that pathogen’s presence is unexpected. More...
29 Nov 2018
Image: A bone marrow smear of a patient with Acute Myeloid Leukemia; dysplastic changes are noted in both the granulocytic and erythroid lineages (Photo courtesy of Peter Maslak).

Acute Myeloid Leukemia Regulatory Networks Identified

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. AML is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. More...
28 Nov 2018
Image: The Chromium Single Cell Gene Expression Solution provides high-throughput, single cell expression measurements that enable discovery of gene expression dynamics and molecular profiling of individual cell types (Photo courtesy of 10X Genomics).

Pregnancy-Related Immune Changes Revealed by Placenta Sequencing

A team of scientists has used single-cell RNA sequencing to map expression profiles in the placenta, focusing on the decidua tissue that forms from the lining of the uterus and placental trophoblast tissue from the fetus that interacts with maternal cells. More...
28 Nov 2018
Image: The ability to detect cell-free circulating tumor DNA in blood provides the opportunity to develop non-invasive tests to measure tumor burden and detect molecular signatures in tumors that are associated with resistance to therapy (Photo courtesy of Huntsman Cancer Institute).

Sensitive Tumor Detection Uses Cell-Free DNA Methylomes

A combination of "liquid biopsy," epigenetic alterations and machine learning has been used to develop a blood test to detect and classify cancer at its earliest stages. The method holds promise of being able to find cancer earlier when it is more easily treated and long before symptoms ever appear. More...
27 Nov 2018
Image: The Quant-iT high sensitivity PicoGreen double-stranded DNA Assay Kit (Photo courtesy of Invitrogen).

Biomarker Found for Prostate Cancer Treatment Response

Prostate cancer is one of the most common cancers in males and has one of the highest five-year survival rate when diagnosed in the localized stage. When diagnosed in the advanced stage or when a localized tumor relapses after the initial local treatment, the usual procedure is to fight it using male hormone (androgen) deprivation therapy. More...
27 Nov 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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