Increased Levels of Serum Amyloid-beta Linked to Development of Cardiovascular Disease

A new review article has summarized studies, which suggest that the Alzheimer’s disease (AD) biomarker amyloid-beta (Abeta) has a causitive link to other age-related conditions such as cardiovascular disease (CVD).

Investigators at Newcastle University (United Kingdom) in collaboration with colleagues in Greece, Germany, Switzerland, and the United States analyzed blood samples from more than 6,600 patients from multiple cohort studies carried out in nine countries.

In the review, which was published in the February 24, 2020, online edition of the Journal of the American College of Cardiology, the investigators described the determinants of Abeta metabolism, summarized the effects of Abeta on atherothrombosis and cardiac dysfunction, discussed the clinical value of Αbeta1-40 in CVD prognosis and patient risk stratification, and presented therapeutic interventions that may alter Abeta metabolism in humans.

Overall, the findings discussed in the review suggested that the higher the level of amyloid-beta in the blood the higher the risk of developing CVD.

Senior author Dr. Konstantinos Stellos, professor of cardiovascular medicine and epitranscriptomics at Newcastle University, said, "Our work has created and put all the pieces of the puzzle together. For the first time, we have provided evidence of the involvement of amyloid-beta in early and later stages of cardiovascular disease. What is really exciting is that we were able to reproduce these unexpected, clinically meaningful findings in patients from around the world. In all cases, we observed that amyloid-beta is a biomarker of cardiovascular ageing and of cardiovascular disease prognosis."

"I am interested in knowing which of my patients is at risk of death and/or recurrent heart attacks," said Professor Stellos. "Measuring amyloid-beta reclassified a large proportion of patients who had a heart attack in the correct risk categories over an established guideline-suggested risk score in independent clinical studies. If blood-based amyloid-beta predicts death in patients with heart disease, does it make a therapeutic target? Our next step is to investigate this."

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