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Molecular Diagnostics

Image: There is currently no standard diagnostic tool or method for the early detection of pancreatic cancer. A test that is sensitive and specific enough to detect pancreatic cancer in its earliest stages has the potential of saving many lives (Photo courtesy of Immunovia AB)

Combined Proteomic/Genomic Method Detects Early Signs of Pancreatic Cancer

A new method that utilized a combined proteomic and genomic approach for profiling serum proteins in solution demonstrated high accuracy for distinguishing samples derived from pancreatic cancer patients and those from healthy controls. More...
29 Jul 2020
Image: Immune events leading up to a rheumatoid arthritis flare (Photo courtesy of Dr. Dana Orange, Rockefeller University)

RNA Sequencing Identifies Novel Cell Class Linked to Rheumatoid Arthritis Flares

A novel class of blood cells has been identified, which may serve as a biomarker able to predict the imminent occurrence of an episodic “flare” in patients with rheumatoid arthritis. More...
28 Jul 2020
Image: Micro Mass Quattro Premier Mass Spectrometer (Photo courtesy of University of Massachusetts Amherst).

Plasma Lipidome Investigated in Hereditary Hemochromatosis

Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption which leads to iron overload and consequently to tissue damage and functional impairment of organs like liver, pancreas, and heart. More...
28 Jul 2020
Image: FoundationOne liquid biopsy assays were used to study the association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer (Photo courtesy of Foundation Medicine).

Circulating Tumor DNA Associated with Triple-Negative Breast Cancer Recurrence

Patients with early-stage triple-negative breast cancer (TNBC) are frequently treated with neoadjuvant chemotherapy, based on the increased risk for recurrence and death associated with this category of tumors. More...
27 Jul 2020
Image: The RaDaR (Residual Disease and Recurrence) assay detects circulating tumor DNA (ctDNA) found in the bloodstream (Photo courtesy of Inivata).

CtDNA Assay for Cancer Recurrence, MRD Applications Demonstrated

Circulating tumor DNA (ctDNA) is found in the bloodstream and refers to DNA that comes from cancerous cells and tumors. Most DNA is inside a cell's nucleus. As a tumor grows, cells die and are replaced by new ones. The dead cells get broken down and their contents, including DNA, are released into the bloodstream. More...
22 Jul 2020
Image: A scanning electron microscope image of normal circulating human blood showing red blood cells, several types of white blood cells including lymphocytes, a monocyte, a neutrophil and many small disc-shaped platelets (Photo courtesy of [U.S.] National Cancer Institute)

COVID-19 Patients with Lymphocytopenia Are Likely to Suffer Severe Disease Symptoms

An easily recognizable feature in blood samples may be an indicator of whether a COVID-19 patient will be likely to suffer from a severe form of the disease. More...
22 Jul 2020
Image: Three-dimensional ball-and-stick model of asymmetric dimethylarginine (Photo courtesy of Wikimedia Commons)

Blood Plasma Biomarker Linked to Middle Age Cognitive Decline

Analysis of plasma asymmetric dimethylarginine concentrations showed that elevated levels of this substance could be used as a biomarker to predict worsening cognitive performance in older adults. More...
21 Jul 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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