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Molecular Diagnostics

Image: Photomicrograph of histology of fibrolamellar hepatocellular carcinoma, showing large polygonal tumors cells with granular eosinophilic cytoplasm (Photo courtesy of Nephron)

Marker Panel Detects Early Liver Cancer with Increased Sensitivity

 Several types of cancer can form in the liver. The most common type of liver cancer is hepatocellular carcinoma, which begins in the main type of liver cell (hepatocyte). Other types of liver cancer, such as intrahepatic cholangiocarcinoma and hepatoblastoma, are much less common. More...
05 Dec 2019
Image: Gene Sequencing identifies pathogenic variants in sudden cardiac death versus controls and asymptomatic adults (Photo courtesy of Massachusetts General Hospital)

Rare Genetic Variants Associated with Sudden Cardiac Death

 A recent study has assessed the prevalence of rare pathogenic variants in sudden cardiac death cases versus controls, and the prevalence and clinical importance of such mutations in an asymptomatic adult population. More...
04 Dec 2019
Image: Researchers introduced the first electrochemical CRISPR-based biosensor to help improve disease diagnostics (Photo courtesy of Richard Bruch, University of Freiburg)

CRISPR-based Electrochemical Biosensor Detects Disease-related MicroRNAs

 A microfluidic chip containing a CRISPR/Cas-based electrochemical biosensor has been introduced as a device for the rapid and precise analysis of the microRNAs involved in various disease states. More...
03 Dec 2019
Image:  False color SEM (scanning electron microscope) micrograph of a Leishmania promastigote. The cell body is shown in orange and the flagellum is in red (Photo courtesy of Wikimedia Commons)

Gene Panel Predicts Failure of Cutaneous Leishmaniasis Treatment

 Patients infected with the protozoan parasite Leishmania braziliensis develop chronic skin lesions that often fail to respond to treatment with anti-parasitic drugs. More...
03 Dec 2019
Image: Structure of the AP2A2 protein (Photo courtesy of Wikimedia Commons)

Genetic Locus with Unique Tandem Repeats Linked to Development of Late-onset Alzheimer’s Disease

 Researchers have discovered evidence of a novel genetic variation linked to the development of late-onset Alzheimer’s disease (AD). More...
02 Dec 2019
Image: The QuantStudio 7 Pro Real-Time PCR System is one of several platforms that the new ChromaCode multi-drug resistant (MDR) panel can be assayed (Photo courtesy of Thermo Fisher Scientific)

Multiplex Panel Debuts for Multi-Drug Resistant Infection Screening

 A multi-drug resistant (MDR) panel detects genetic signatures of resistance to specific antibiotics in pathogens that are commonly thought of as hospital acquired, and is designed to be used as a screening test for infection control and isolation of asymptomatic carriers. More...
28 Nov 2019
Image: Immunofluorescence image of microglial cells stained red with antibody. DNA shown in blue (Photo courtesy of Wikimedia Commons)

Non-coding Regions of the Genome in Microglia Linked to Alzheimer’s Disease Risk

 A recently published paper linked risk of developing Alzheimer’s disease (AD) to enhancers - non-coding DNA regions of the genome - that were present in microglia but not in other types of brain cells such as neurons or astrocytes. More...
28 Nov 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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