We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Events

24 Feb 2024 - 28 Feb 2024
05 Mar 2024 - 07 Mar 2024

Raman Spectroscopy Test Could Improve Lyme Disease Diagnostics

By LabMedica International staff writers
Posted on 09 Jan 2023
Print article
Image: New research aims to improve Lyme disease diagnostics (Photo courtesy of Texas A&M University)
Image: New research aims to improve Lyme disease diagnostics (Photo courtesy of Texas A&M University)

Lyme disease, the fastest growing vector-borne illness in the U.S., is challenging to diagnose and can only be treated in the early stages of infection. Once the infection spreads to the nervous and muscular systems, it is both harder to detect and less susceptible to antibiotics. Now, scientists are focusing on improving Lyme disease treatment outcomes by developing a test that’s both more accurate and more efficient than the current test for the infection.

Scientists at Texas A&M University (College Station, TX, USA) are testing Raman spectroscopy, a technique used to detect vibrations at the molecular level, as a diagnostic tool for Lyme disease. The results of their second paper published on Raman spectroscopy as a diagnostic tool for Lyme disease demonstrate that blood samples from mice and humans infected with the Lyme pathogen were more accurately identified with the Raman spectroscopy test than with the two-tiered serology, the only diagnostic method currently approved to diagnose Lyme disease in humans in the U.S.

The increased accuracy of Raman spectroscopy testing could improve Lyme disease diagnostic practices for both humans and animals believed to have been in contact with the disease. For animals, the new test would require a smaller sample that could easily be taken in the field away from a veterinary clinic or hospital, thus improving mobile veterinary practices. For humans, Raman spectroscopy testing could significantly decrease the amount of time needed to complete testing, increase the accuracy of the diagnosis, lower the cost of diagnosing the disease, and improve overall health outcomes by definitively diagnosing the disease earlier.

The scientists are in the process of validating the test through additional studies, and if the test is validated, it could become an important tool for diagnosing Lyme disease worldwide, especially in more remote areas outside the U.S. where the disease is prevalent, by enabling testing outside of traditional medical and hospital settings. Their first paper published on Raman spectroscopy is the first proof-of-concept study to have explored Raman spectroscopy to diagnose mice infected with the Lyme pathogen. Their second paper included data on testing Raman spectroscopy on samples from mice infected with European Lyme pathogens. The scientists expect to publish more findings in about two years from the next phase of their research that entails testing human samples in a blind manner.

“We’re trying to develop a better test that would be simple, inexpensive and accurate. By accurate, I mean highly sensitive and highly specific at the same time,” said Dr. Artem Rogovskyy, an associate professor at the Texas A&M School of Veterinary Medicine & Biomedical Sciences, who is conducting the research along with Dr. Dmitry Kurouski, an assistant professor in the Texas A&M Department of Biochemistry & Biophysics and the Department of Biomedical Engineering.

Related Links:
Texas A&M University 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Reagent Reservoirs
Reagent Reservoirs

Print article

Channels

Clinical Chemistry

view channel
Image: Wireless Point-of-Care Testing for Hepatitis B Virus (Photo courtesy of Chulalongkorn University)

Wireless Hepatitis B Test Kit Completes Screening and Data Collection in One Step

Hepatitis B, a significant global health concern, is responsible for chronic liver diseases like cirrhosis and liver cancer which is one of the most common cancers worldwide. The challenge with hepatitis... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more

Pathology

view channel
Image: The photoacoustic spectral response sensing instrument is based on low-cost laser diodes (Photo courtesy of Khan et al., doi 10.1117/1.JBO.29.1.017002)

Compact Photoacoustic Sensing Instrument Enhances Biomedical Tissue Diagnosis

The pursuit of precise and efficient diagnostic methods is a top priority in the constantly evolving field of biomedical sciences. A promising development in this area is the photoacoustic (PA) technique.... Read more

Industry

view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.