We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Elevated Glycolated Hemoglobin in Young People Predicts Likelihood of Diabetes or Cardiovascular Disease in Adulthood

By LabMedica International staff writers
Posted on 19 Aug 2020
A review of blood test results from more than 14,000 young people suggested that measurement of glycated hemoglobin (HbA1c) was a specific and useful nonfasting marker for identify high-risk youth who could benefit from lifestyle interventions to prevent diabetes and cardiovascular risk in adulthood.

The American Diabetes Association (ADA) has estimated that more than 34 million or roughly 10% of Americans have diabetes, and many of these cases are undiagnosed. More...
Furthermore, obesity-associated type II diabetes is rapidly becoming more prevalent in children, due to the rise in obesity, poor diet, and sedentary lifestyles.

In this light, investigators at Johns Hopkins University (Baltimore, MD, USA) evaluated the performance of current clinical definitions of prediabetes and diabetes based on glycolated hemoglobin (HbA1c), fasting plasma glucose (FPG), either HbA1c or FPG, or both HbA1c and FPG (confirmatory definition) to identify youth at high cardiometabolic risk. For this study, the investigators reveiwed blood test data on 14,119 young people aged 10 to 19 from the U.S. National Health and Nutrition Examination Surveys ( NHANES) conducted between 1999 and 2016.

Results revealed that associations with cardiometabolic risk were consistently stronger and more specific for HbA1c-defined hyperglycemia (specificity = 98.6%; sensitivity = 4.0%) than FPG-defined hyperglycemia (specificity = 90.1%; sensitivity = 19.4%). Furthermore, 51% of subjects with HbA1c-defined hyperglycemia were obese compared to just 29% with hyperglycemia defined by the fasting glucose test.

"Our study demonstrates that HbA1c is a useful non-fasting test for identifying high-risk youth who could benefit from lifestyle interventions to prevent diabetes and cardiovascular disease later in life," said senior author Dr. Elizabeth Selvin, professor of epidemiology, at Johns Hopkins University. "Some pediatricians have already been using HbA1c, but there has not been sufficient guidance from pediatric organizations. I am hoping that these results will help inform and guide the use of this important screening tool in clinical practice."

The study was published in the August 10, 2020, online edition of the journal Pediatrics.

Related Links:

Johns Hopkins University


Gold Member
Quantitative POC Immunoassay Analyzer
EASY READER+
Collection and Transport System
PurSafe Plus®
Gold Member
Immunochromatographic Assay
CRYPTO Cassette
New
Gold Member
Automatic CLIA Analyzer
Shine i9000
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New evidence shows viscoelastic testing can improve assessment of blood clotting during postpartum hemorrhage (Photo courtesy of 123RF)

Viscoelastic Testing Could Improve Treatment of Maternal Hemorrhage

Postpartum hemorrhage, severe bleeding after childbirth, remains one of the leading causes of maternal mortality worldwide, yet many of these deaths are preventable. Standard care can be hindered by delays... Read more

Immunology

view channel
Image: When assessing the same lung biopsy sample, research shows that only 18% of pathologists will agree on a TCMR diagnosis (Photo courtesy of Thermo Fisher)

Molecular Microscope Diagnostic System Assesses Lung Transplant Rejection

Lung transplant recipients face a significant risk of rejection and often require routine biopsies to monitor graft health, yet assessing the same biopsy sample can be highly inconsistent among pathologists.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.