We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
24 Feb 2021 - 28 Feb 2021
Virtual Venue
03 Mar 2021 - 05 Mar 2021
Virtual Venue

Elevated Glycolated Hemoglobin in Young People Predicts Likelihood of Diabetes or Cardiovascular Disease in Adulthood

By LabMedica International staff writers
Posted on 19 Aug 2020
Print article
Model of the HbA1c molecule (image courtesy of Biologic Models)
Model of the HbA1c molecule (image courtesy of Biologic Models)
A review of blood test results from more than 14,000 young people suggested that measurement of glycated hemoglobin (HbA1c) was a specific and useful nonfasting marker for identify high-risk youth who could benefit from lifestyle interventions to prevent diabetes and cardiovascular risk in adulthood.

The American Diabetes Association (ADA) has estimated that more than 34 million or roughly 10% of Americans have diabetes, and many of these cases are undiagnosed. Furthermore, obesity-associated type II diabetes is rapidly becoming more prevalent in children, due to the rise in obesity, poor diet, and sedentary lifestyles.

In this light, investigators at Johns Hopkins University (Baltimore, MD, USA) evaluated the performance of current clinical definitions of prediabetes and diabetes based on glycolated hemoglobin (HbA1c), fasting plasma glucose (FPG), either HbA1c or FPG, or both HbA1c and FPG (confirmatory definition) to identify youth at high cardiometabolic risk. For this study, the investigators reveiwed blood test data on 14,119 young people aged 10 to 19 from the U.S. National Health and Nutrition Examination Surveys ( NHANES) conducted between 1999 and 2016.
Platinum Supplier
SARS-CoV-2/Influenza A & B/RSV Test
BIOSYNEX® AMPLIQUICK® SARS-COV-2 and Respiratory Triplex
Coronavirus Test
COVID-19 Coronavirus Real Time PCR Kit
Visit expo >

Results revealed that associations with cardiometabolic risk were consistently stronger and more specific for HbA1c-defined hyperglycemia (specificity = 98.6%; sensitivity = 4.0%) than FPG-defined hyperglycemia (specificity = 90.1%; sensitivity = 19.4%). Furthermore, 51% of subjects with HbA1c-defined hyperglycemia were obese compared to just 29% with hyperglycemia defined by the fasting glucose test.

"Our study demonstrates that HbA1c is a useful non-fasting test for identifying high-risk youth who could benefit from lifestyle interventions to prevent diabetes and cardiovascular disease later in life," said senior author Dr. Elizabeth Selvin, professor of epidemiology, at Johns Hopkins University. "Some pediatricians have already been using HbA1c, but there has not been sufficient guidance from pediatric organizations. I am hoping that these results will help inform and guide the use of this important screening tool in clinical practice."

The study was published in the August 10, 2020, online edition of the journal Pediatrics.

Related Links:

Johns Hopkins University

Print article



view channel
Image: The Leica Bond III stainer is fully automated Immunohistochemical and In Situ Hybridization (IHC and ISH stainer) (Photo courtesy of Leica Biosystems).

Mismatch Repair/Microsatellite Instability Evaluated Using Cytology Effusion Specimens

DNA mismatch repair (MMR) status is routinely assessed in colorectal and endometrial carcinoma as a method of cancer prevention, surveillance in patients with Lynch syndrome and their families, and for... Read more


view channel

Roche Renews Partnership with Sysmex to Deliver Hematology Testing Solutions

Under the new framework of a Global Business Partnership Agreement (GBP) signed between Roche (Basel, Switzerland) and Sysmex Corporation (Kobe, Japan), both the companies have renewed their commitment... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.