We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBE SCIENTIFIC, LLC

BÜHLMANN LABS

BÜHLMANN designs, develops, manufactures and sells medical diagnostic products and kits (IVD or RUO) in the areas of ... read more Featured Products: More products

Download Mobile App




Fecal Calprotectin Predicts Complete Mucosal Healing in UC

By LabMedica International staff writers
Posted on 13 Nov 2017
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by a disease course involving relapses and remissions. More...
Historically, clinical remission was the major treatment target for patients with UC.

The use of repeated endoscopy to verify mucosal healing (MH) is invasive, inconvenient, and expensive, and may present a risk of significant complications such as colonic perforation. Therefore, noninvasive surrogate markers indicating endoscopic healing have been investigated to replace the repeated endoscopic procedures.

Scientists at the University of Ulsan College of Medicine (Seoul, Republic of Korea) collected 181 fecal samples from 181 consecutive UC patients between April 2015 and September 2016. Collected data included birth date, sex, date of UC diagnosis, family history of IBD, smoking status, maximum disease extent, and medications. The laboratory test results, partial Mayo Score (pMS), and colonoscopic imaging findings at Fecal Calprotectin (FC) level measurement were retrospectively reviewed.

FC levels were measured using the Quantum Blue Calprotectin rapid test (Bühlmann Laboratories AG, Schönenbuch, Switzerland), and high-range kit measuring 100–1,800 mg/kg was used. The following laboratory parameters were recorded at the time of FC level measurement: complete blood cell count on the XE-2100 (Sysmex Corporation, Kobe, Japan), including white blood cell count, hemoglobin level, hematocrit value, and platelet count; erythrocyte sedimentation rate (ESR); and serum chemistry values on the Cobas 8000 modular analyzer (Roche Diagnostics, Basel, Switzerland), and the AU5800 (Beckman Coulter, Brea, CA, USA), including C-reactive protein (CRP) and albumin levels.

The investigators found that among the biochemical markers, FC levels exhibited significant correlations with the CRP and serum albumin. The other laboratory values including white blood cell count, hematocrit values, platelet and ESR exhibited weaker correlations with the FC levels, as compared to both the CRP and serum albumin levels. The FC cut-off level of 187.0 mg/kg indicated complete mucosal healing with a sensitivity and specificity of 0.857 and 0.891, respectively.

The authors concluded that the FC level is significantly correlated with the clinical disease activity index, endoscopic indices, and serum inflammatory biomarkers in a Korean UC cohort. FC is highly predictive of complete mucosal healing in UC. UC endoscopic index of severity (UCEIS) exhibits a stronger correlation with the FC level; as compared to the Mayo endoscopic subscore (MES). Thus, FC could be used as a reliable noninvasive indicator for evaluating disease activity and mucosal healing in UC. The study was published on October 23, 2017, in the journal BMC Gastroenterology.


Gold Member
Veterinary Hematology Analyzer
Exigo H400
Serological Pipet Controller
PIPETBOY GENIUS
New
Silver Member
Autoimmune Hepatitis Test
LKM-1-Ab ELISA
New
Drug Test Kit
DrugCheck 3000
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.