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Pathology

Image: The Mastercycler X50 for polymerase chain reactions (Photo courtesy of Eppendorf).

Microbiome Helps Identify Patients with Early-Stage Cancer

Nearly 10,000 people are diagnosed with pancreatic cancer in the UK each year, with less than 1% surviving beyond ten years. More...
12 Feb 2019
Image: Positron Emission Tomography (PET) scans of the brain of a normal patient (left) versus an Alzheimer\'s disease patient, which may have been detected earlier by measuring Neurofilament light chain (NfL) in CSF (Photo courtesy of Science Photo Library).

Blood Test Detects Brain Damage Years before Symptoms

Alzheimer's disease is a major cause of dementia that destroys brain cells and tissue. As the brain damage spreads, it leads to symptoms such as confusion, memory loss, and diminishing capacity to function. Eventually, the person can no longer lead an independent life. More...
07 Feb 2019
Image: Various types of data analysis using BeadStudio Methylation Module (Photo courtesy of Phoebe Lu).

DNA Methylation Test Detects Early Aggressive Prostate Cancer

Liquid biopsies that noninvasively detect molecular correlates of aggressive prostate cancer (PCa) could be used to triage patients, reducing the burdens of unnecessary invasive prostate biopsy and enabling early detection of high-risk disease. More...
06 Feb 2019
Image: Vials of cerebrospinal fluid that can be sequenced for cell-free DNA in glioma patients (Photo courtesy of James Heilman, MD).

CSF Liquid Biopsy Sequencing Tracks Glioma Evolution

Genetic tumor profiling of gliomas is used to classify disease and guide therapy, but involves brain surgery for tissue collection; repeated tumor biopsies may be necessary for accurate genotyping over the course of the disease. More...
06 Feb 2019
Image: Porphyromonas gingivalis gingipains in the neurons of Alzheimer\'s brain. P. gingivalis gingipains = red, neurons = yellow, astrocytes = green (Photo courtesy of Cortexyme).

Bacterial Pathogen Discovered in Brains of Alzheimer's Patients

Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles. More...
06 Feb 2019
Image: The EsophaCap is packed into a gelatin capsule that dissolves in a patient’s stomach exposing the sponge, which gently collects cells from the whole surface of the esophagus when withdrawn. Cellular material will be examined using cytological, immunohistochemical and genomic methods (Photo courtesy of Swallow the Sponge).

Simple Inexpensive Test Screens for Esophageal Cancer

Cancer of the esophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it's often too late to save the patient. More...
05 Feb 2019
Image: Blood test for organ transplant monitoring using DNA sequencing (Photo courtesy of National Heart, Lung and Blood Institute).

Blood Test Improves Detection of Severe Transplant Rejection

Lung transplant recipients have the shortest survival rates among patients who get solid organ transplantation of any kind as only about half live past five years. More...
04 Feb 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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