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Pathology

Image: The NanoDrop 2000 Spectrophotometer used to quantify and assess purity of DNA, RNA, and Proteins (Photo courtesy of Thermo Fisher Scientific).

CD MicroRNA Marks Subtypes with Differing Outcomes

Crohn’s disease (CD), one of the primary inflammatory bowel diseases (IBD), is a chronic inflammatory condition of the gastrointestinal tract resulting from an aberrant immune response to the enteric microbiota in a genetically susceptible host. More...
25 Oct 2018
Image: A diagram of electric field–induced release and measurement (EFIRM) platform (Photo courtesy of EZLife Bio).

Novel Technology Enables Detection of Early-Stage Cancer

Non-small-cell lung carcinoma (NSCLC) is often fatal because most cases are not diagnosed until they are so advanced that surgical intervention is no longer possible. To improve outcomes a blood test has been developed to detect lung cancer earlier in the disease. More...
24 Oct 2018
DIASOURCE (A Biovendor Company)
Image: The NextSeq 550x instrument, a benchtop high-throughput sequencing system (Photo courtesy of Illumina).

Epigenomic Method Developed to Detect Pancreatic Cancer

Pancreatic cancers are typically diagnosed at late stage where disease prognosis is poor as exemplified by a 5-year survival rate of 8.2%. Earlier diagnosis would be beneficial by enabling surgical resection or earlier application of therapeutic regimens. More...
24 Oct 2018
Image: The Guardant360 gene panel is a technology capable of isolating circulating tumor DNA in blood to identify genomic alterations in tumor genomic panel. This test allows identify genomic alterations and match them to treatment options (Photo courtesy of Guardant Health).

Test Identifies More Treatable Cancer Mutations Than Biopsies

Standard of care therapies that target specific mutations have changed the face of cancer treatment, and screening for such mutations, which can be drivers of both disease growth and treatment resistance. This can often be done with a biopsy of tumor tissue, but sometimes that tissue is hard to obtain or does not have sufficient DNA for analysis. More...
22 Oct 2018
Image: The LightCycler 480 II is a high-performance, medium- to high-throughput PCR platform (Photo courtesy of Roche).

Novel Fecal Biomarker Found for Colorectal Cancer

Colorectal cancer (CRC) is a lethal disease that has been rising in incidence during recent decades, placing an increasingly important burden on the healthcare system worldwide and gut microbial dysbiosis contributes to the development of this deadly disease. More...
17 Oct 2018
Image: A histopathology of interstitial lung disease showing acute injury with necrosis. Necrosis (N) is a harbinger of infection in an acutely ill patient. Infection always leads the differential diagnosis in this situation, even if special stains are negative (Photo courtesy of Professor K.O. Leslie).

Microbiome Alterations Influence Lung Disease Prognosis

Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of lung diseases affecting the interstitium, which is the tissue and space around the air sacs of the lungs. More...
16 Oct 2018
Image: The biotech company Igenomix has developed the first molecular test to identify the nine most common bacterial species underlying chronic endometritis, a persistent inflammation of the uterine endometrium that particularly affects women with endometriosis (Photo courtesy of Patricia Inacio, PhD).

Test Developed for Uterine Infections Impacting Fertility

Approximately 10% of women in the general population may have chronic endometritis, but among infertile women undergoing IVF, the rate is 15%, with rates estimated as high as 60% among women experiencing recurring implantation failure or miscarriage. More...
11 Oct 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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