We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics

Biocartis SA

Biocartis is a commercial stage molecular diagnostics company that develops diagnostics technology platforms for mult... read more Featured Products: More products

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
05 Sep 2020 - 09 Sep 2020
Virtual Venue

Rapid Genomic Profiling of Colon Cancers Improves Therapy Selection

By LabMedica International staff writers
Posted on 09 Jul 2020
Print article
Image: The Idylla system is a fully-automated, real-time polymerase chain reaction (PCR) based molecular testing system designed to offer results in a minimal amount of time (Photo courtesy of Biocartis).
Image: The Idylla system is a fully-automated, real-time polymerase chain reaction (PCR) based molecular testing system designed to offer results in a minimal amount of time (Photo courtesy of Biocartis).
Colorectal cancer is a malignant tumor arising from the inner wall of the large intestine (colon) or rectum. Colorectal cancer is the third leading cause of cancer in both men and women in the USA. Most colorectal cancers develop from polyps. Removal of colon polyps can aid in the prevention of colorectal cancer.

Treatment of colorectal cancer depends on the location, size, and extent of cancer spread, as well as the health of the patient. Management of colorectal cancer warrants mutational analysis of KRAS/NRAS when considering anti–epidermal growth factor receptor therapy and BRAF testing for prognostic stratification.

Scientists at the Geisel School of Medicine (Lebanon, NH, USA) and their colleagues enrolled 874 colorectal cancer cases from 20 laboratories between November 2017 and December 2018. The teams compared a new cartridge-based laboratory testing device called the Idylla automated system (Biocartis US, Inc, Jersey City, NJ, USA) using the KRAS and NRAS-BRAF cartridges to current standard-of-care testing methods.

The multicenter teams reported that the average turnaround time for test results could be cut by more than 65% from 15 days to five days, with some results available in a single day. The significant decrease in wait time means patients can begin appropriate treatments for colorectal cancer much sooner. The simplicity and ease of use of the new technology compared with other molecular techniques also makes it suitable for integration into clinical laboratories of any size, including those that may not have much molecular expertise.

In collecting the data, the study also addressed the use of minimal tissue from the patient sample. Gregory J. Tsongalis, PhD, a Professor of Pathology and Laboratory Medicine and senior author of the study, said, “One of the study sites included several 1-mm tissue biopsy samples, showing that even smaller tissue-based specimens can be successfully analyzed by Idylla. Our results are in line with findings of other studies showing successful analyses using very small tissue amounts, including those deemed too small for standard molecular testing methods.”

The authors concluded that the described cartridge-based system offers rapid and reliable testing of clinically actionable mutation in colorectal cancer specimens directly from formalin-fixed, paraffin-embedded tissue sections. Its simplicity and ease of use compared with other molecular techniques make it suitable for routine clinical laboratory testing. The study was published on June 11, 2020 in the American Journal of Clinical Pathology.

Print article


Molecular Diagnostics

view channel
Image: Micrograph of gold nanostar biosensors used to detect cancer-related microRNAs (Photo courtesy of Duke University School of Engineering)

Nanostar Biosensors Use Raman Scattering for Direct Detection of Cancer-Related MicroRNAs

A novel non-invasive nanoparticle-based assay detects cancer-related microRNAs without use of labels or target amplification. MicroRNAs (miRNAs) comprise a class of about 20 nucleotides-long RNA fragments... Read more

Industry News

view channel
Image: ChemWell RPR Analyzer (Photo courtesy of Awareness Technology, Inc.)

Awareness Technology Announces ChemWell RPR Analyzer - The Most Significant Innovation in Syphilis Testing in Last 30 Years

Awareness Technology, Inc. (Palm City, FL, USA) has announced the most significant innovation in syphilis testing in the last 30 years with the launch of the ChemWell RPR automated nontreponemal analyzer... Read more
Copyright © 2000-2020 Globetech Media. All rights reserved.