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Pathology

Image: The NovaSeq 6000 sequencing system platform (Photo courtesy of Illumina).

Diverse Chronic Kidney Diseases Diagnosed with Exome Sequencing

Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders in adults, including chronic kidney disease, which affects more than 1 in 10 persons globally. More...
08 Jan 2019
Image: A comparison of OncoScan array CGH assay–derived metastasis potential scores (MPSs) for indolent primary tumor (iPT) and metastasis-prone primary tumor (mPT) samples (Photo courtesy of Albert Einstein College of Medicine).

Rapid Next-Gen Sequencing Method Predicts Prostate Cancer Risks

Prostate cancer is the most commonly diagnosed male cancer and the second leading cause of cancer deaths among men in the USA, with approximately 220,000 new diagnoses and approximately 27,000 deaths each year. More...
08 Jan 2019
DIASOURCE (A Biovendor Company)
Image: Genome-wide human SNP array 6.0 GeneChip (Photo courtesy of Affymetrix).

Metastatic Colorectal Cancer Linked to Transcription Factors

Colorectal cancer (CRC) is a kind of malignant human tumor with high mortality around the world. The incidence of colorectal cancer shows a gender difference and is prone to the elderly. More...
03 Jan 2019
Image: A new screening method for cervical cancer has proven 100% accurate in testing (Photo courtesy of Health News).

Epigenetic Cervical Cancer Test Has Perfect Detection Rate

Human papillomavirus (HPV) ‐based cervical cancer screening requires triage of HPV positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. More...
02 Jan 2019
Image: The Oncomine Focus Assay is performed using the Ion Torrent technology. The test is designed to help oncologists expedite selection of a treatment plan for their patients in days instead of weeks (Photo courtesy of Thermo Fisher Scientific).

Sequencing Assay Adopted for Advanced Lung Cancer Reflex Testing

Guidelines are rapidly moving toward upfront profiling with next-generation sequencing (NGS) of all advanced lung cancers, but there are still practical issues with this testing method that can limit clinical testing and prevent or delay patients being started on targeted therapies. More...
31 Dec 2018
Image: Histopathology of a typical neuroblastoma with rosette formation (Photo courtesy of Dr. Mark Applebaum, MD).

Neuroblastoma Molecular Analysis Leads to Prognostic Markers

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. It most frequently starts from one of the adrenal glands, but can also develop in the neck, chest, abdomen, or spine. More...
27 Dec 2018
Image: SureSelect Target Enrichment Systems (Photo courtesy of Agilent Technologies).

Genetic and Epigenetic Features Found in Glioma Tumors

Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder that is characterized by cutaneous findings, most notably café-au-lait spots and axillary freckling, by skeletal dysplasias, and by the growth of both benign and malignant nervous system tumors, most notably benign neurofibromas. More...
27 Dec 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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