We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBE SCIENTIFIC, LLC

BIO-RAD LABORATORIES

Provides full range of instrumentation, reagent kits, software and quality control systems to clinical laboratories. ... read more Featured Products: More products

Download Mobile App




Diabetes Blood Markers Linked to Alzheimer’s Disease Pathology

By LabMedica International staff writers
Posted on 09 Sep 2020
Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. More...
In its early stages, memory loss is mild, but late-stage Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment.

Type 2 diabetes is a known risk factor for cognitive impairment and Alzheimer’s disease, but the underlying mechanisms are still unknown. Insulin resistance has been associated with amyloid accumulation in cognitively normal middle-aged and late middle-aged individuals, but not in older age groups.

Neurologists at the University of Eastern Finland (Kuopio, Finland) and their colleagues investigated the association of blood markers of diabetes with beta-amyloid accumulation detected in PET scans in older people at risk of dementia. The study population included 41 participants aged 60 to 77 years from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) who had available data on insulin resistance and type 2 diabetes-related blood markers.

The team analyzed 12 markers related to glucose and lipid metabolism using the multiplex suspension array system Bio-Plex Luminex 200 instrument, (Bio-Rad Laboratories, Hercules, CA, USA), with the Bio-Plex Pro Human Diabetes 10-plex panel (C-peptide; ghrelin; GIP, gastric inhibitory polypeptide; GLP-1, glucagon-like peptide-1; glucagon; insulin; leptin; PAI-1; resistin; visfatin) and 2-plex panel (adiponectin, adipsin). The homeostatic model assessment of insulin resistance index (HOMA-IR) was calculated based on fasting blood insulin and glucose measures. APOE genotype was also determined.

The scientists reported that the participants’ mean age (±SD) was 71.1 ± 5.0 years, 51% were female, 15% had diabetes, 29% were APOE ɛ4 carriers, and 39% had amyloid positive PiB-PET scans. In the logistic regression model adjusted for diabetes status and APOE genotype, higher levels of insulin, HOMA-IR, C-peptide, and PAI-1were significantly associated with lower odds of amyloid positivity. After FDR correction, these four markers were significant only at the 90% confidence level. The coefficient of PAI-1 was insignificant in models including insulin, HOMA-IR, and C-peptide, but significant for fasting glucose, HbA1c, and all other tested analytes.

Alina Solomon, MD, PhD, an Associate Professor of Clinical Medicine Neurology and the senior author of the study, said, “The results could also suggest that in people with diabetes and vascular pathology, less amyloid accumulation in the brain may be needed to trigger the onset of Alzheimer’s dementia.”

The authors concluded that the main strength of their study was the assessment of a comprehensive assay of IR and type 2 diabetes-related markers in relation to brain amyloid-β accumulation on PiB-PET, which has not been previously done. The study was published on August 18, 2020 in the Journal of Alzheimer’s Disease.





Gold Member
Troponin T QC
Troponin T Quality Control
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Chlamydia Trachomatis Test
Aptima Chlamydia Trachomatis Assay
New
Drug Test Kit
DrugCheck 3000
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.