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Pathology

Image: The Bioanalyzer RNA 6000 Nano assay provides reliable and reproducible characterization of total RNA and mRNA from multiple sample types, from as low as 5 ng of total RNA (Photo courtesy of Agilent)

Respiratory Syncytial Virus Bronchiolitis Has Different Subtypes

Bronchiolitis is the leading cause of hospitalization in infants in the USA, accounting for about 110,000 hospitalizations annually. In addition to the substantial acute morbidity, around 30% of infants hospitalized for bronchiolitis (“severe bronchiolitis”) subsequently develop asthma in childhood. More...
30 Jun 2021
Image: A blood test for glucose may reveal hyperglycemia which has been evaluated as a risk factor in pancreatic cancer (Photo courtesy of Amit Akirov, MD)

Hyperglycemia Evaluated as a Risk Factor in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (pancreatic cancer) has a five-year survival rate of 9%. Most patients are diagnosed with metastatic disease due to late presenting symptoms and only 10% to 20% are able to undergo surgery with a curative intent. More...
23 Jun 2021
Image: Genetic variants are associated with unexplained sudden cardiac death in both adult White and African American individuals (Photo courtesy of Latin American Society of Interventional Cardiology)

Genetic Variants Associated with Unexplained Sudden Cardiac Death

As many as 450,000 Americans die every year from a sudden, fatal heart condition, and in slightly more than one in ten cases the cause remains unexplained even after an autopsy. Most sudden cardiac deaths are caused by abnormal heart rhythms called arrhythmias and the most common life-threatening arrhythmia is ventricular fibrillation. More...
22 Jun 2021
Image: Schematics of how the Signatera bespoke mPCR NGS assay works (Photo courtesy of Natera)

CtDNA Analysis Assesses Early Relapse Detection in Colorectal Cancer

Colorectal cancer (CRC) is a type of cancer that begins in the large intestine (colon). The colon is the final part of the digestive tract. Colon cancer typically affects older adults, though it can happen at any age. It usually begins as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Over time some of these polyps can become colon cancers. More...
17 Jun 2021
Image: The QIAsymphony SP enables sample preparation of DNA, RNA, and bacterial and viral nucleic acids from a wide range of starting materials (Photo courtesy of Qiagen)

Liquid Biopsies Detect Pediatric Bone Tumors Based on Epigenetic Profiles

Sequencing of cell-free DNA (cfDNA) in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. As a consequence, cfDNA analysis holds great promise for precision oncology and personalized therapies, and is currently evaluated in a broad range of clinical studies. More...
17 Jun 2021
Image: The CFX384 Touch real-time PCR detection system (Photo courtesy of Bio-Rad)

Genomic Differences Cause Racial Disparities in Prostate Cancer

Prostate cancer is a disease defined by the abnormal growth of cells. These abnormal cells can proliferate in an uncontrolled way and, if left untreated, form tumors which may metastasize or spread to other parts of the body. Prostate cancer (PCa) is the most common solid organ malignancy in men, with 174,650 new diagnoses and 31,620 deaths expected in 2019 in the USA alone. More...
17 Jun 2021
Image: (A) Mucormycetes demonstrated broad hyphae with wavy, nonparallel walls and few septa. (B) Nonmucormycetes, which were predominantly Aspergillus species by culture, demonstrated thin delicate hyphae with parallel walls and frequent septa. (C and D) Candida species were distinctive for a mixture of yeasts and pseudohyphae (Photo courtesy of UT Health San Antonio)

Intraoperative Frozen Section Detect Acute Invasive Fungal Rhinosinusitis

Acute invasive fungal rhinosinusitis (AIFRS) is a potentially lethal and rapidly progressive disease. It primarily affects immunocompromised or diabetic patients, in whom organisms that are ubiquitous, but usually harmless can invade mucosa and rapidly disseminate to the orbit and cranial cavity. More...
09 Jun 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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