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Technology

Image: The CDC 2019 Novel Coronavirus (2019-nCoV) Real-Time Reverse Transcriptase (RT)–PCR Diagnostic Panel detects the SARS-CoV-2 virus in upper and lower respiratory specimens. The new P-BEST approach provides both an eight-fold improvement in testing efficiency as well as an eight-fold reduction in cost of PCR testing (Photo courtesy of Center for Disease Control and Prevention)

New Pooling Strategy Increases Efficiency and Reduces Cost of COVID-19 PCR Tests

A new way of manipulating samples for COVID-19 testing of asymptomatic and symptomatic individuals provides both an eight-fold increase in testing efficiency, as well as an eight-fold reduction in test costs. More...
31 Aug 2020
Image: Schematic diagram of the OvCa-Chip microsystem that recreates vascular endothelium–mediated platelet extravasation in ovarian cancer (Photo courtesy of Texas A&M College of Engineering).

Microfluidic Device Explores Ovarian Cancer Interactions

In many cancers, platelet interactions with circulating tumor cells and their role in metastasis have been studied extensively. In ovarian cancer, platelet extravasation into the tumor and resulting metastasis is thought to be regulated mostly by the vascular endothelium. More...
26 Aug 2020
The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample. While the ELISA test is sensitive, patients can have high levels of cTnI in the blood without having heart disease, which can lead to expensive and unnecessary treatments for patients. More...
20 Aug 2020
Cells in wells of a 96 well-plate before (A) and after (B) lysis cell by Direct PCR (B1) and Chelex100 (B2) (Photo courtesy of University Hospital Hamburg‐Eppendorf).

Two Simple Methods Prepare DNA Suitable For Digital PCR

Although DNA of high quality can be easily prepared from cultured cells with commercially available kits, many studies involve a large number of samples which increases the cost drastically. More...
19 Aug 2020
Image: The Melioidosis DS assay principle: A dipstick is placed into a well containing patient serum diluted in dipstick master mix (running buffer, detection antibody and control reagent) (Photo courtesy of Medical University of Graz).

Serological Dipstick Assay Developed for Melioidosis

The Gram-negative environmental pathogen Burkholderia pseudomallei, causes the severe disease melioidosis. It is highly endemic in southeast Asia and northern Australia, but recent studies suggest that it is also present in many other parts of the world where it is severely underreported. More...
05 Aug 2020
Image: A prototype of the handheld ammonia blood detector and associated test strips (Photo courtesy of Thomas Veltman).

Portable Blood Ammonia Detector Developed

Ammonia is a natural product of digestion that is usually processed into urea by the liver and passed out of the body in urine. Too much ammonia in the blood can cause mental and physical dysfunction and is a concern for people with liver disease or genetic conditions that hinder ammonia metabolism. More...
04 Aug 2020
Image: Schematic diagram of the fully-automatic blood-typing chip exploiting bubbles for quick dilution and detection (Photo courtesy of Tokyo University of Science).

Micro-Lab on a Chip Detects Blood Type Within Minutes

Blood transfusion, if performed promptly, is a potentially life-saving intervention for someone losing a lot of blood. However, blood comes in several types, some of which are incompatible with others. Transfusing an incompatible blood type can severely harm a patient. More...
27 Jul 2020
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LabMedica's Lab Technology channel informs on laboratory medicine techniques, while keeping an eye on new hardware, LIM software, consumables, and lab trends, techniques and safety.
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