We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
04 May 2021 - 07 May 2021
Virtual Venue

Paper-Based Microneedle Skin Patch for Continuous Glucose Monitoring

By LabMedica International staff writers
Posted on 23 Sep 2020
Print article
Image: Illustration demonstrating painless and biodegradable microneedles on a paper patch (Photo courtesy of University of Tokyo)
Image: Illustration demonstrating painless and biodegradable microneedles on a paper patch (Photo courtesy of University of Tokyo)
A microneedle skin patch for the continuous monitoring of an individual’s glucose level was designed to be a painless and disposable screening and diagnostic test for diabetes patients, as well as those with pre-diabetes.

Porous microneedles are expected to have a variety of potential applications in diagnostics owing to their ability to penetrate human skin painlessly and extract bio‐fluid by capillary action. Investigators at the University of Tokyo (Japan) have applied this technology for screening and monitoring levels of glucose.

The microneedles were fabricated by pouring a mixture of a melted biodegradable polymer and salt into the cone-shaped cavities of a micro-mold while applying heat. The mold was then inverted with the needles on the lower side, and the device was placed on top of a sheet of paper with high pressure applied from above. The high pressure forced the polymer mixture into the pores of the paper, securing the attachment and allowing fluid drawn through the needles to pass effortlessly into the paper. After removal from the mold, the needles were cooled in a solution that removed the salt, leaving behind pores, through which fluid could flow into the paper. A paper glucose sensor was then attached to the paper base of the needle array. The final product was disposable and biodegradable, and its use did not require any medical expertise or training.

The paper‐based glucose sensor was used to demonstrate the absorption property of the microneedles, and showed successful sample extraction and glucose concentration analysis from agarose gel‐based skin mimics. The investigators maintained that the platform had the potential to integrate various different paper‐based bio‐sensors in order to function as painless and disposable rapid screening and diagnostic tests for many metabolites.

"We have overcome this problem by developing a way to combine porous microneedles with paper-based sensors," said senior author Dr. Beomjoon Kim, professor in the institute of industrial science at the University of Tokyo. "The result is low-cost, disposable, and does not require any additional instruments."

The microneedle device was described in the August 2020 issue of the journal Medical Devices & Sensors.

Related Links:
University of Tokyo

Gold Supplier
Respiratory Panel with SARS-CoV-2
BioFire Respiratory 2.1-EZ (RP2.1- EZ) Panel With SARS-CoV-2
COVID-19 Anitibody Test
SARS-CoV-2 Antigen Test
ESPLINE SARS-CoV-2 Antigen Test
Preterm Delivery Test (phIGFBP-1)
Actim Partus 1ngeni

Print article
BIOHIT  Healthcare OY



view channel
Image: The Luminex Aries® System (Photo courtesy of Luminex Corporation)

DiaSorin to Acquire Luminex to Broaden Positioning in Molecular Diagnostics Space

DiaSorin S.p.A. (‎Saluggia‎, Italy) has announced that its Board of Directors has unanimously approved and signed a definitive merger agreement for DiaSorin to acquire Luminex Corporation (Austin, TX,... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.