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Clinical Chemistry

Image: A scanning electron photomicrograph (SEM) of prostate cancer cells (Photo courtesy of Prostate Cancer UK).

Low Testosterone Men Less Likely to Have Prostate Cancer

Prostate cancer affects more than 170,000 men each year in the USA, of who almost 30,000 die from the disease. While it is not yet known what causes the condition, a number of risk factors have been identified, such as age, ethnicity, and genetic mutations. More...
24 Nov 2017
Image: Variations in phosphate levels in the blood may pose risk to cardiovascular health (Photo courtesy of Dr. Steve Petryk).

Low Serum Phosphate Linked to Risk of Heart Attack

Cardiovascular disease is a leading cause of mortality and morbidity worldwide, and high serum phosphate is an established risk factor for coronary artery disease, particularly in patients with chronic kidney disease. More...
22 Nov 2017
Image: Enzyme-linked immunosorbent assay (ELISA) kits for the measurement of fecal and serum zonulin (Photo courtesy of DRG International).

Fecal Zonulin Elevated in Crohn’s Disease and Smokers

Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin's participation in inflammatory bowel diseases (IBD). More...
20 Nov 2017
Image: The UF-1000i automated urine particle analyzer (Photo courtesy of Sysmex).

Urine Particle Analyzer Compared with Standard Methods

Urinary tract infections (UTIs) are characterized by the presence of microbial pathogens within the urinary tract, and they represent one of the most common infections identified in both hospitalized and clinic patients. Most UTIs are easily treated without difficulty. More...
20 Nov 2017
Image: The LC UltiMate 3000 high performance liquid chromatography (HPLC) system coupled with an LTQ Velos Pro mass spectrometry system (Photo courtesy of Thermo Fisher Scientific).

New Methods Developed to Diagnose TB and HIV

The bacteria responsible for tuberculosis (TB) can lurk in a person's lung tissue for decades before producing active, infectious TB disease and it is estimated that a third of the global population may have such dormant infections, with 5% to 10% progressing to active disease. Detecting TB is notoriously challenging. More...
15 Nov 2017
Image: A range of Elecsys and cobas Reagents for thyroid function test kits (Photo courtesy of Roche).

High Thyroid Hormone Levels Associated with Arterial Disease

Atherosclerosis is the process of progressive thickening and hardening of the walls of arteries from fat deposits on their inner lining. Atherosclerosis progresses insidiously from a subclinical condition to the clinical onset of vascular events to death. More...
15 Nov 2017
Image: An immunohistochemistry of the new biomarker DNAJB9 greatly improves diagnostic sensitivity for the rare kidney disease, fibrillary glomerulonephritis (Photo courtesy of Mayo Clinic).

Potential Autoantigen Identified in Aggressive Kidney Disease

Fibrillary glomerulonephritis (FGN) is an aggressive kidney disease, and nearly half of patients become dependent on dialysis within several years of diagnosis. No unique clinical markers of FGN have been identified to help diagnose FGN, and current tests involve time-consuming analyses with light microscopy, immunofluorescence, and electron microscopy. More...
13 Nov 2017
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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