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Clinical Chemistry

Image: A micrograph of cerebral amyloid angiopathy with senile plaques in the cerebral cortex consistent of amyloid beta, as may be seen in Alzheimer disease (Photo courtesy of Nephron).

Subthreshold Amyloid Predicts Tau Deposition in Aging

The progressive nature of Alzheimer's disease (AD) necessitates the earliest possible detection of pathological or cognitive change if disease progression is to be slowed. The rate at which the protein beta-amyloid (Aβ) accumulates into the sticky plaques associated with Alzheimer's disease (AD) is already slowing by the time a patient would be considered to have preclinical AD. More...
10 May 2018
Image: The Simoa 2.0, ultrasensitive immunoassay platform used for measuring plasma tau and serum NfL (Photo courtesy of Quanterix).

Blood-Based Biomarker Assessed for Subtle Brain Injury

A high-sensitive blood test can aid concussed hockey players when it might be safe to return to play. The test has identified a superior blood-based biomarker for assessing subtle brain injury. More...
10 May 2018
Image: The MS ESI LC-TOF Micromass LCT 4 (Photo courtesy of Waters / UC Irvine).

Blood Biomarkers May Allow Easier Concussion Detection

Specific small molecules in blood plasma may be useful in determining whether someone has sustained a mild traumatic brain injury (mTBI), commonly known as a concussion. More...
03 May 2018
Image: The nanoLC-Ultra 1D+ for nanoflow liquid chromatography (Photo courtesy of Eksigent).

Biomarkers Identified for Irritable Bowel Syndrome

The causes of gastrointestinal complaints in irritable bowel syndrome (IBS) remain poorly understood. Altered nerve function has emerged as an important pathogenic factor as IBS mucosal biopsy supernatants consistently activate enteric and sensory neurons. More...
02 May 2018
Image: Validation of beta-amyloid dimers in Alzheimer’s Brains (Photo courtesy of Institute for Research in Biomedicine).

Beta-Amyloid Dimers Found in Alzheimer's Patient Brains

The most widely used biomarkers for the early detection of Alzheimer's disease (AD) are currently the concentrations of beta-amyloid (Aβ) and phosphorylated Tau in cerebrospinal fluid. However, it has been observed that not all individuals with alterations in these biomarkers develop the disease. More...
01 May 2018
Image: A liquid chromatography-tandem mass spectrometer (LC-MS/MS) (Photo courtesy of University of Michigan).

Low Total Testosterone Linked to Chronic Disease

A male's total testosterone level may be linked to more than just sexual health and muscle mass preservation. Low amounts of the hormone could also be associated with chronic disease, even among men 40 years of age and younger. More...
01 May 2018
Image: The G5 mobile continuous glucose monitoring (CGM) system (Photo courtesy of Dexcom).

Continuous Glucose Monitor Benefits Diabetics

Continuous glucose monitors (CGM) offer significant, daily benefits to people with type 1 diabetes, providing near-real time measurements of blood sugar levels, but they can be expensive. More...
24 Apr 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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