AI Identifies Advanced Lung Cancer Patients Who Respond to Immunotherapy

In a new study, researchers utilized artificial intelligence (AI) and digital pathology techniques to improve the accuracy of such evaluations.

The study by scientists at the Yale School of Medicine (New Haven, CT, USA) focused on how AI-based digital assessment could fare against traditional manual methods in scoring the PD-L1 immune biomarker. The goal was to see if a novel immunotherapy treatment called atezolizumab could be beneficial for patients suffering from advanced non-small cell lung cancer (NSCLC). To undertake this research, they drew upon data from the IMpower 110 phase III trial, which examined the effectiveness of atezolizumab against chemotherapy for treating advanced NSCLC. Through both manual and AI-guided evaluations of tumor cells, the team discovered that the AI system was more efficient at identifying patients as PD-L1 positive than manual methods.

Moreover, the study found that both AI-based and traditional manual scoring techniques were equally competent at predicting patient results, including how long patients lived and how long it took before the cancer progressed. Additionally, the AI system aided in confirming that for patients with a particular subtype of NSCLC known as squamous histology, the existence of PD-L1+ lymphocytes was linked to better outcomes in terms of slowing down disease progression when treated with atezolizumab.

“Our study suggests that artificial intelligence has the ability to improve the identification of PD-L1 positive patients by providing a predictive accuracy that was better than manual scoring,” said Roy S. Herbst, lead study author and deputy director of Yale Cancer Center. “The research underscores the potential of digital pathology and AI tools in enhancing PD-L1 scoring accuracy for both clinical practice and clinical trials.”

“The insights gained with AI and digital scoring could make diagnosing and choosing the right treatment easier,” added Herbst. “Our data shows that this AI technology can help refine strategies for treating advanced non-small cell lung cancer.”

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Yale School of Medicine