We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

DIASORIN

DiaSorin develops, produces and commercializes diagnostic tests for a wide range of clinical areas. The company’s tes... read more Featured Products: More products

Download Mobile App




Serum Thyroglobulin Assays Compared for Differentiated Thyroid Carcinoma

By LabMedica International staff writers
Posted on 05 Oct 2020
Measurement of serum thyroglobulin (Tg) plays a key role in the post‐thyroidectomy management of differentiated thyroid carcinoma (DTC). More...
In this context, the performance of new‐generation thyroglobulin assay has clinical implications in the follow‐up of DTC patients.

Following total thyroidectomy, serum Tg levels are expected to be undetectable. On this basis, postoperative circulating Tg levels are used as a tumor marker to assess completely surgical resection and recurrence in the follow‐up of well‐differentiated thyroid cancer (DTC). The addition of Tg concentration of fine‐needle washouts (FNA‐Tg) of the suspicious lymph node to fine‐needle aspiration cytology (FNAC) showed improved prediction of lymph node metastases (LNM).

Medical Scientists at the University of Naples “Federico II” (Naples, Italy) selected a total of 91 residual serum samples between September 2019 and December 2019. These subjects comprised 35 men and 56 women, and their mean age was 48.2 ± 17.0 years. Serum postsurgical Tg lower than 1‐2 ng/mL is a strong predictor of remission, whereas Tg levels more than 10‐30 ng/mL are associated with persistent or recurrent disease. Study samples were from 21 patients with pathologically proven DTC and control samples from 70 (16 patients with benign thyroid disease and 54 apparently healthy subjects).

Tg was determined by using two different chemiluminescence immunoassays (CLIA). Specifically, these included Liaison (Tg-L, Liaison XL, Diasorin, Saluggia, Italy) and Beckman UniCeL DxI800 (Tg-A, Access, Beckman Coulter Inc, Brea, CA, USA). Thyroglobulin antibodies (TgAbs) were determined by Siemens ADVIA Centaur (Siemens Healthcare Diagnostics Products Ltd., Llanberis, UK).

The investigators reported that the results showed that Tg‐L was highly correlated with Tg‐A for both values ranging between 0.2 and 50 ng/mL) and higher than 50 ng/mL. For Tg values lower than 0.2 ng/mL, the overall concordance rate was 92%. Moreover, they tested seven fine‐needle aspiration washout fluids (FNA), showing an overall concordance rate in discriminating negative and positive of 100%. Finally, they found no interference by Tg auto‐antibodies (TgAbs) for both Tg‐L and Tg‐A. Conversely, rheumatoid factor (RF) interferes with Tg‐A, but not with Tg‐L in one patient with no relapsing thyroid carcinoma.

The authors concluded that preliminary data on a small study population suggests a good correlation between Liaison Tg II assay and the well‐established Access immunoassay. Further studies on larger population are needed to confirm the findings and to evaluate the clinical performance of this new immunoassay in the follow‐up of DTC patients. The study was published on September 20, 2020 in the Journal of Clinical Laboratory Analysis.



Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
Serological Pipet Controller
PIPETBOY GENIUS
New
Drug Test Kit
DrugCheck 3000
New
PSA Assay
CanAg PSA EIA
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: Increased polysialic acid in schizophrenia patients represents a potential diagnostic tool and possible target for treatment (Photo courtesy of 123RF)

New Technique for Measuring Acidic Glycan in Blood Simplifies Schizophrenia Diagnosis

Polysialic acid is a unique acidic glycan predominantly found in brain regions associated with memory and emotion, but it is also present in the bloodstream. Research has shown that blood levels of polysialic... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.