We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Biomarkers Correlated with Idiopathic Inflammatory Myopathy

By LabMedica International staff writers
Posted on 25 Sep 2018
Print article
Image: The Immage 800 immunochemistry system (Photo courtesy of Beckman Coulter).
Image: The Immage 800 immunochemistry system (Photo courtesy of Beckman Coulter).
Patients with idiopathic inflammatory myositis (IIM) typically present with muscle weakness, myalgia and in case of dermatomyositis (DM) also skin involvement. Arthralgia is often present, but the articular manifestations are usually mild and non-destructive.

As rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are not routinely tested in idiopathic inflammatory myositis (IIM), little is known about their prevalence and clinical implications in this patient group. In anti-synthetase syndrome (ASS), presence of ACPA is reportedly associated with more severe and erosive arthritis.

Medical scientists at the University Hospitals Leuven (Leuven, Belgium) analyzed serum samples from 121 patients. Thirty diagnosed with polymyositis, 41 with dermatomyositis, 37 with ASS, five with necrotizing autoimmune myopathy or seven with overlap myositis and one with inclusion body myositis. RF was evaluated by nephelometry; anti-CCP antibodies were identified using fluoro enzyme immunoassays. Values above 40 IU/mL and 7 U/mL were considered positive for RF and ACPA, respectively.

The investigators observed no significant differences were observed between RF-positive and RF- negative IIM patients. The prevalence of RF and ACPA was 9.09% and 4.96%, respectively. The team observed a trend for RF-positive IIM patients to be older than RF-negative IIM patients and to more frequently carry ACPA antibodies and have lower forced expiratory volume in 1 second (FEV1) values (72% versus 88%). There was no statistically significant difference between patients who tested positive for both RF and ACPA, and patients who tested negative for both antibodies. The presence of RF or ACPA was not significantly associated with interstitial lung disease.

The authors concluded that their study demonstrated that RF and ACPA are prevalent in patients with IIM, but the detected prevalence is lower than the prevalence reported in previous studies in connective tissue diseases including IIM. Their results did not show a clear association between RF or ACPA positivity and specific clinical features or the occurrence of ILD or arthritis. The study was published originally published online on July 25, 2018, in the journal RMD Open.

Related Links:
University Hospitals Leuven

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The study showed the blood-based cancer screening test detects 83% of people with colorectal cancer with specificity of 90% (Photo courtesy of Guardant Health)

Blood Test Shows 83% Accuracy for Detecting Colorectal Cancer

Colorectal cancer is the second biggest cause of cancer deaths among adults in the U.S., with forecasts suggesting 53,010 people might die from it in 2024. While fewer older adults are dying from this... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more

Microbiology

view channel
Image: The new platform is designed to perform blood-based diagnoses of nontuberculosis mycobacteria (Photo courtesy of 123RF)

New Blood Test Cuts Diagnosis Time for Nontuberculous Mycobacteria Infections from Months to Hours

Breathing in nontuberculous mycobacteria (NTM) is a common experience for many people. These bacteria are present in water systems, soil, and dust all over the world and usually don't cause any problems.... Read more

Industry

view channel
Image: These new assays are being developed for use on the recently introduced DxI 9000 Immunoassay Analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter and Fujirebio Expand Partnership on Neurodegenerative Disease Diagnostics

Beckman Coulter Diagnostics (Brea, CA, USA) and Fujirebio Diagnostics (Tokyo, Japan) have expanded their partnership focused on the development, manufacturing and clinical adoption of neurodegenerative... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.