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Image: The BC-6800 benchtop automatic hematology analyzer (Photo courtesy of Mindray).

Hematology Analyzer Screens for Malaria in Clinical Setting

Malaria is a vector-borne infectious disease that continues to have high morbidity and mortality globally. Diagnosis based only on clinical symptoms has very low specificity as there is no combination of symptoms that reliably distinguishes malaria from other causes of fever or influenza. More...
14 Aug 2019
Image: A blood smear from a patient with non-Hodgkin lymphoma showing very large lymphocytes (Photo courtesy of Venngage).

BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk

Inherited mutations in BRCA1 and BRCA2 genes are most typically associated with an increased risk of developing breast and ovarian cancer. BRCA2 was the third most frequently mutated gene (14 occurrences) among 3,006 survivors of childhood cancer, with the highest number observed among survivors of lymphoma. More...
09 Aug 2019
BIOHIT  Healthcare OY
Image: A histopathology of chronic interstitial nephritis in end-stage kidney disease. There is diffuse interstitial scarring with a nonspecific mononuclear infiltrate (Photo courtesy of Agnes B. Fogo MD, Michael Kashgarian MD).

Abnormal Metabolite Observed in Early CKD Patients

Chronic kidney disease (CKD) has been a growing health burden worldwide, and the patients with CKD continue to suffer from a wide range of complication including electrolyte imbalance, fluid overload, bone and mineral metabolism disorder to anemia. More...
06 Aug 2019
Image: A blood smear of a patient with Sickle Cell Disease. Polychromatophilic reticulocytes are present (small single arrow). Target cell (large single arrow) and sickle cell (double arrow) can be seen in this view (Photo courtesy of John Lazarchick).

Noninvasive Prenatal Test Developed for Sickle Cell Disease Risk

Sickle cell disease (SCD) is an autosomal recessive disease, meaning that a child has to inherit two mutated copies of the hemoglobin gene to develop it, one from each parent. If both parents have sickle cell trait, there is a 25% chance the child will have SCD. More...
01 Aug 2019
Image: Bone marrow aspirate of a patient with myeloid leukemia associated with Down’s syndrome. The smear includes frequent atypical megakaryocytes. Blasts are increased (11%). As in the peripheral blood, a subset of the blasts has cytoplasmic blebs (Photo courtesy of Elizabeth L. Courville, MD).

Genetic Changes Linked to Leukemia in Down’s Syndrome Children

Of the 30% of children with Down's syndrome who are found to have 'myeloid preleukemia', only 10% of those will go on to develop myeloid leukemia (3% of all children with Down's syndrome). Until now, it was not understood why only some children with the GATA1 mutation were progressing to full leukemia, while others were not. More...
24 Jul 2019
Image: An immunoglobulin G (IgG)-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis (Photo courtesy of Institut Pasteur).

Immunoglobulins and Neutrophils Play Unexpected Role in Anaphylaxis

Anaphylaxis may be brought about by various substances, including drugs (antibiotics or neuromuscular blocking agents), food and insect venom. Anaphylaxis is a hyperacute allergic reaction caused by an inappropriate immune response following the introduction of a usually harmless antigen into the body. More...
23 Jul 2019
Image: The ABL800 FLEX blood gas analyzer (Photo courtesy of Radiometer Medical).

Neutrophil‐Lymphocyte Ratio and Lactate Predict Mortality in Septic Patients

Sepsis is the primary cause of death from infection. It is also one of the leading causes of intensive care unit (ICU) mortality, despite early administration of antibiotics and hemodynamic management. More...
23 Jul 2019

The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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