We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Urine Osmolality Measurement Evaluated on Automated Analyzer

By LabMedica International staff writers
Posted on 06 Oct 2020
Urinalysis is a convenient and non‐invasive screening tool for use in both an outpatient and inpatient setting. More...
Automated flow cytometry‐based urine analyzer is increasingly being used to identify and enumerate cells and particles in urine specimens. It measures electrical conductivity which could be transformed to osmolality.

The osmolality of urine, which indicates the quantity of osmotically active particles, can be estimated by the specific gravity (SG). While the SG correlates with urine osmolality, the direct measurement of urine osmolality is more accurate and is considered the gold standard for determining the hydration status of the body and its ability to concentrate urine.

Laboratory Medical Scientists at the Pusan National University Yangsan Hospital (Yangsan, South Korea) collected 270 random urine samples, also known as spot samples, for analysis that included osmolality testing from May 2018 to July 2018. The precision of urine osmolality measurement by the UF‐5000 (Sysmex Corporation, Kobe, Japan) was evaluated for 20 days and four times a day for two concentrations. The linearity and detection capability were evaluated according to the Clinical and Laboratory Standards Institute guidelines. A comparison analysis between the UF‐5000 and the OsmoPro equipment (Advanced Instruments, Norwood, MA, USA) was performed in the laboratory using random urine samples from patients.

The laboratorians reported that the laboratory‐based coefficient variations were less than 5%. Urine osmolality using the UF‐5000 has a verified linear range (R2 = 0.997). Within the comparison analysis, the mean difference was not large (−7.72%), but each differences were largely dispersed with 95% limits of agreement (LoA) from −70.5 to 55.06%, and the mean absolute difference −28.3 mOsm/kg with 95% LoA from −295.13 to 238.45 mOsm/kg. Cohen's kappa value was 0.54. The mean ± SD osmolality measured by the OsmoPro and UF5000 was 450.33 ± 227.51 mOsm/kg and 421.99 ± 221.53 mOsm/kg, respectively.

The authors concluded that the conductivity‐based measurement of osmolality has reliable precision and linearity within a specific range that includes the reference range. Considering the good accessibility of routine analyzer, UF‐5000 can be used to determine whether the urine osmolality is within the reference or should be measured by freezing depression method. The study was published on September 24, 2020 in the Journal of Clinical Laboratory Analysis.

Related Links:
Pusan National University Yangsan Hospital
Sysmex Corporation
Advanced Instruments



Gold Member
Veterinary Hematology Analyzer
Exigo H400
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Gold Member
Blood Gas Analyzer
Stat Profile pHOx
New
Anti-Thyroid Peroxidase Assay
LIAISON Anti-TPO
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.