We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Biomarkers Explored in Patients with Acute Coronary Syndromes

By LabMedica International staff writers
Posted on 28 Aug 2018
Well-developed coronary collateral arteries are associated with improved survival in patients with coronary artery disease. More...
A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activation as macrophages.

Vascular endothelial growth factor (VEGF) signaling is a critical step in angiogenesis. VEGF-A is one of five related growth factors, which bind primarily to three tyrosine kinase receptors with different affinity. Cardiac ischemia modulates the regulation and expression of several VEGF family ligands and receptors via Hypoxia Inducible Factor-1 (HIF-1).

A large team of scientists working with those at the University of Otago (Christchurch, New Zealand) recruited 2,067 patients after admission to Christchurch or Auckland City Hospitals with a diagnosis of acute coronary syndrome (ACS), from July 2002 to January 2009. In the Christchurch subgroup of the cohort collateral vessels were graded according to the Rentrop classification. Coronary artery anatomy, severity of coronary stenoses and the myocardium at risk were assessed according to the Brandt score in the same subgroup.

Plasma samples were collected and stored at −80 °C. Soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble vascular endothelial growth factor receptor (sKDR) were analyzed using chemiluminescent quantitative sandwich enzyme immunoassays detection limits, sFlt-1 3.5 pg/mL and sKDR 4.6 pg/mL. High performance liquid chromatography (HPLC) measurement of pterins was performed using a, Sil-20A HPLC with auto-sampler, with a RF-20Axls fluorescence detector. Genomic DNA was extracted for genotyping was performed by real-time polymerase chain reaction (RT-PCR). Circulating levels of Brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) were also assayed.

The team found that at baseline, levels of sFlt-1 were significantly correlated with age, alcohol consumption, NT-proBNP, BNP and other covariates relevant to cardiovascular pathophysiology. Total neopterin levels were associated with alcohol consumption at baseline. 7,8 dihydroneopterin was associated with BMI. The A allele of VEGFR-2 variant rs1870377 was associated with higher plasma sFlt-1 and lower levels of sKDR at baseline. Baseline plasma sFlt-1 was univariately associated with all-cause mortality with and in a Cox’s proportional hazards regression model sFlt-1 and pterins were both associated with mortality independent of established predictors.

The authors concluded that there was an independent association of both plasma sFlt-1 and total pterin levels with all-cause and cardiovascular mortality in a cohort of patients with coronary artery disease followed up for several years after an index acute coronary event. The study was published on August 15, 2018, in the journal BMC Cardiovascular Disorders.

Related Links:
University of Otago


Gold Member
Blood Gas Analyzer
Stat Profile pHOx
Portable Electronic Pipette
Mini 96
New
Sample Transportation System
Tempus1800 Necto
New
Urine Chemistry Control
Dropper Urine Chemistry Control
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The VENTANA HER2 (4B5) test is now CE-IVDR approved (Photo courtesy of Roche)

Companion Diagnostic Test Identifies HER2-Ultralow Breast Cancer and Biliary Tract Cancer Patients

Breast cancer is the most common cancer in Europe, with more than 564,000 new cases and 145,000 deaths annually. Metastatic breast cancer is rising in younger populations and remains the leading cause... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.