Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




C-Reactive Protein Assessed for Albuminuria Severity

By LabMedica International staff writers
Posted on 21 Feb 2018
Diabetes is a major cause of early morbidity and mortality in the world and is the leading cause of renal failure, non-traumatic amputations and blindness in adults. More...
Chronic hyperglycemia causes irreversible structural and functional changes in cells leading to the development of microvascular and macrovascular complications.

C-reactive protein is one of the most sensitive markers of subclinical inflammation, and its serum concentration is an indicator of intensity of low-grade chronic inflammation of the arterial wall. Measurement of total albuminuria in 24-hour urine is the gold standard for early detection of nephropathy and its prevention and the most sensitive prognostic factor for assessing the risk of developing clinical nephropathy.

Scientists at Cantonal Hospital Zenica (Zenica, Bosnia and Herzegovina) and their colleagues carried out a prospective study included 69 patients with diabetes mellitus type 2 (T2DM), both sexes (24 males, 45 females), aged 30-82 years. They were divided into two groups: 40 patients with T2DM and normoalbuminuria (T2DM-NA); and 29 patients with T2DM and microalbuminuria (T2DM-MA). Patients were hospitalized at the Department of Internal Medicine, Cantonal Hospital Zenica, in the period January-April 2014.

Biochemical analyses were performed for serum creatinine, urea, high sensitive C-reactive protein (hsCRP), and albumin in 24-hour urine samples. Immunonephelometry measurement of hsCRP was performed on the Nephelometer Analyzer BN II. The 24 urinary albumin measurements were performed using immunoturbidimetric method (PETINIA), and the HbA1c was measured by turbidimetric inhibition immunoassay (TINIA) and an analysis was performed using the Siemens’ Dimension Clinical Chemistry System analyzer.

The team reported that the frequency of patients in T2DM-NA and T2DM-MA groups was not significantly different in relation to sex and age. There was significant difference in relation to duration of diabetes. The mean glucose and HbA1c levels were significantly higher in T2DM-NA group comparing to T2DM-MA group. Serum creatinine, urea and hsCRP were significantly higher in T2DM-MA group compared to T2DM-NA group. Urinary albumin showed significantly positive correlation with the hsCRP, urea and creatinine. A one unit (mg/L) increase in hsCRP concentration was associated with 11.5% increase of odds of microalbuminuria.

The authors concluded that significantly higher values of serum hsCRP in patients with type 2 diabetes mellitus and microalbuminuria in comparison to those with normoalbuminuria as well as the correlation of values of inflammatory marker with urinary albumin implicate a low-grade inflammation in the progression of diabetic nephropathy. The study was published on February 1, 2018, in the journal Medicinski Glasnik.

Related Links:
Cantonal Hospital Zenica


Gold Member
Immunochromatographic Assay
CRYPTO Cassette
Collection and Transport System
PurSafe Plus®
Alcohol Testing Device
Dräger Alcotest 7000
HBV DNA Test
GENERIC HBV VIRAL LOAD VER 2.0
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New evidence shows viscoelastic testing can improve assessment of blood clotting during postpartum hemorrhage (Photo courtesy of 123RF)

Viscoelastic Testing Could Improve Treatment of Maternal Hemorrhage

Postpartum hemorrhage, severe bleeding after childbirth, remains one of the leading causes of maternal mortality worldwide, yet many of these deaths are preventable. Standard care can be hindered by delays... Read more

Immunology

view channel
Image: The CloneSeq-SV approach can allow researchers to study how cells within high-grade serous ovarian cancer change over time (Photo courtesy of MSK)

Blood Test Tracks Treatment Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is often diagnosed at an advanced stage because it spreads microscopically throughout the abdomen, and although initial surgery and chemotherapy can work, most... Read more

Industry

view channel
Image: The collaboration aims to improve access to Hb variant testing with the Gazelle POC diagnostic platform (Photo courtesy of Hemex Health)

Terumo BCT and Hemex Health Collaborate to Improve Access to Testing for Hemoglobin Disorders

Millions of people worldwide living with sickle cell disease and other hemoglobin disorders experience delayed diagnosis and limited access to effective care, particularly in regions where testing is scarce.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.