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Pathology

Image: The RevertAid First Strand cDNA Synthesis Kit is a complete system for efficient synthesis of first strand cDNA from RNA templates (Photo courtesy of Thermo Fisher Scientific).

Prognostic Signature Described in HPV-Positive Cell Carcinomas

Human papilloma virus (HPV) is an etiological agent of oropharyngeal squamous cell carcinoma (OPSCC). Patients with HPV+ OPSCC have high long-term survival rates: however, current radiation protocols are aggressive and can result in life-long morbidities, including difficulty swallowing, chronic dry-mouth, and altered speech. More...
23 Jan 2019
Image: A sketch of µLAS chip with two independent channels actuated with the same pressure and voltage. Each channel contains a funnel region that functions to separate and concentrate DNA in line (Photo courtesy of University of Lausanne).

Genetic Methods Rapidly Diagnoses Huntington's Disease

People with Huntington's disease suffer from jerky body movements and decreasing mental abilities. The condition usually leads to death 15 to 20 years after diagnosis. The cause of the disease is a region in the Huntingtin gene (HTT) that is absent in healthy people. More...
23 Jan 2019
Image: A diagram of the role of CD69 in atherosclerosis (Photo courtesy of the Spanish National Center for Cardiovascular Research).

CD69 Biomarker Expression Predicts Atherosclerosis Risk

Atherosclerosis is a disease characterized by the accumulation of lipid deposits in the artery wall, but the disease is usually not detected until after it has caused a clinical event such as a myocardial infarction or stroke. More...
22 Jan 2019
Image: The Synergy H1 multi-mode microplate reader (Photo courtesy of BioTek).

Urinary Detection Method Developed for Prostate Cancer

Prostate cancer (PCa) is one of the most common types of malignancy worldwide and is the second leading cause of cancer death among men. This cancer tends to be asymptomatic and slow growing, often with onset in young men, but usually not detected until the age of 40 to 50 years. More...
22 Jan 2019
Image: The APOL1 G1 and G2 risk alleles in 111 global reference populations (Photo courtesy of the Icahn School of Medicine).

Latinos and Hispanics Prone to Kidney Disease Gene Variant

Risk variants in the apolipoprotein A-I (APOL1) gene on chromosome 22, which were first discovered in African Americans, confer a substantially increased risk of kidney disease, early-onset hypertension, and cardiovascular disease, although disease risk is modified by other genetic factors and by environmental factors. More...
21 Jan 2019
Image: A histopathology of squamous cell carcinoma of the esophagus (Photo courtesy of Nephron).

Age-Related Remodeling Linked to Normal Aging

Mutations in some cancer driver genes can arise in seemingly normal esophageal tissue as early as in childhood, becoming increasingly common with age and in response to alcohol or cigarettes. More...
21 Jan 2019
Image: A diagram showing normal and polycystic ovary syndrome, in the latter the ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs (Photo courtesy of Mayo Clinic).

New Risk Loci Identified for Polycystic Ovary Syndrome

Polycystic ovary syndrome is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. More...
09 Jan 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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