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Pathology

Image: The two sets of charts compare the recommendations for managing patients with pancreatic cysts based on either CompCyst or standard-of-care pathology (Photo courtesy of the American Association for the Advancement of Science).

Test Improves Accuracy in Identifying Precancerous Pancreatic Cysts

Pancreatic cysts are common and often pose a management dilemma, because some cysts are precancerous, whereas others have little risk of developing into invasive cancers. Early, accurate detection of pancreatic cancer is a high priority. More...
30 Jul 2019
Image: A diagram illustrating peripheral artery disease in the lower limbs (Photo courtesy of US National Institute of Health).

GWAS Links Novel Loci to Peripheral Artery Disease Risk

Peripheral artery disease (also called peripheral arterial disease, PAD)) is a common circulatory problem in which narrowed arteries reduce blood flow to the limbs. PAD most commonly affects arteries in the legs. Both PAD and coronary artery disease (CAD) are caused by atherosclerosis. More...
25 Jul 2019
DIASOURCE (A Biovendor Company)
Image: An immunohistochemical staining IL-17A expression in (A) M. mycetomatis, and (B) S. somaliensis. IL-17A staining was seen as a brown cytoplasmic staining in cells (Photo courtesy of University of Khartoum).

Immune Molecules Expressed Inside Mycetoma Lesions

Mycetoma is a persistent, progressive granulomatous inflammatory disease caused either by fungi or by bacteria. Characteristic of this disease is that the causative agents organize themselves in macroscopic structures called grains. These grains are surrounded by a massive inflammatory reaction. More...
24 Jul 2019
Image: The MiSeq System: access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling (Photo courtesy of Illumina).

Next-Generation Sequencing Identifies Monogenic Diabetes

Monogenic diabetes is seen mainly in maturity onset diabetes of the young (MODY), and accounts for 1%–2% of all diabetes cases. In adults, monogenic diabetes is difficult to distinguish from common diabetes causes. More...
23 Jul 2019
Image: EndoPredict is a next-generation breast cancer recurrence test that integrates tumor biology and pathology to accurately predict early and late (5-15 years) recurrence with an individualized absolute chemotherapy benefit (Photo courtesy of Myriad Genetics).

Multigene Expression Profiling Assays Compared for Cancer

A cost-effectiveness analysis recently published has added another factor to the ongoing competition and debate between various companies offering genomic breast cancer recurrence assays. More...
19 Jul 2019
Image: Ultra-Sensitive TP53 sequencing for cancer detection reveals progressive clonal selection in normal tissue over a century of human lifespan (Photo courtesy of University of Washington).

Low-Frequency TP53 Gene Mutations Also Found in Healthy Women

Worldwide, more than 250,000 new cases of ovarian cancer are diagnosed each year, and two-thirds of these women die from the disease. This high mortality is largely due to the high frequency of metastasis before diagnosis and a lack of effective screening and early detection methods. More...
19 Jul 2019
Image: The Epi ProColon screening test is a blood-based colorectal cancer screening test is an in vitro polymerase chain reaction assay for the qualitative detection of Septin9 gene methylation in DNA isolated from the patient’s plasma (Photo courtesy of Epigenomics).

Blood Test Complements Colonoscopy for Lynch Syndrome Patients

Lynch syndrome (LS) subjects are genetically predisposed to a high risk for colorectal cancer (CRC) and regular colonoscopy is currently the only CRC screening option recommended for these subjects, although compliance is suboptimal. More...
16 Jul 2019
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Serological Pipets
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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