We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Microfluidic Device Isolates Circulating Tumor Cell Clusters

By LabMedica International staff writers
Posted on 03 Jul 2019
The three main challenges of cancer treatment are metastases, recurrence, and acquired therapy resistance. More...
These challenges have been closely linked to circulating cancer cell clusters.

About 90% of cancer deaths are due to metastases, when tumors spread to other vital organs, and it has recently been realized that it's not individual cells but rather distinct clusters of cancer cells that circulate and metastasize to other organs.

A team of scientists led by San Diego State University (San Diego, CA, USA) has shown how a well-known passive micromixer design (staggered herringbone mixer - SHM) can be optimized to induce maximum chaotic advection within antibody-coated channels of dimensions appropriate for the capture of cancer cell clusters. The device’s principle design configuration is called: Single-Walled Staggered Herringbone (SWaSH).

The design of the device makes use of 32 channels, each of 200 μm width and 100 μm spacing, which will increase the available chip surface to cross-sectional area by approximately 1.4-fold. Numerous simulations were performed by varying different properties of the HB pattern, such as channel configuration, and flow velocities to optimize for our deterministic factor cell-to-surface interactions. The Cy5-labeled streptavidin was utilized to visualize the cross-linked and functionalized alginate hydrogel coating within the micro channels. Images were captured using a fluorescence Zeiss 200M microscope.

Peter Teriete, PhD, an assistant professor and co-author of the study, said, “Our device's channel design had to generate microfluidic flow characteristics suitable to facilitate cell capture via antibodies within the coated channels. So we introduced microfeatures, herringbone recesses, to produce the desired functionality. We also developed a unique alginate hydrogel coating that can be readily arrayed with antibodies or other biomolecules. By connecting bioengineering with materials science and basic cancer biology, we were able to develop a device and prove that it performs as desired.” The study was published on June 18, 2019, in the journal AIP Advances.

Related Links:
San Diego State University


New
Gold Member
Serological Pipets
INTEGRA Serological Pipets
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Silver Member
Fibrinolysis Assay
HemosIL Fibrinolysis Assay Panel
New
Automated PCR Setup
ESTREAM
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: An “evolutionary” approach to treating metastatic breast cancer could allow therapy choices to be adapted as patients’ cancer changes (Photo courtesy of 123RF)

Evolutionary Clinical Trial to Identify Novel Biomarker-Driven Therapies for Metastatic Breast Cancer

Metastatic breast cancer, which occurs when cancer spreads from the breast to other parts of the body, is one of the most difficult cancers to treat. Nearly 90% of patients with metastatic cancer will... Read more

Pathology

view channel
Image: A real-time trial has shown that AI could speed cancer care (Photo courtesy of Campanella, et al., Nature Medicine)

AI Accurately Predicts Genetic Mutations from Routine Pathology Slides for Faster Cancer Care

Current cancer treatment decisions are often guided by genetic testing, which can be expensive, time-consuming, and not always available at leading hospitals. For patients with lung adenocarcinoma, a critical... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.