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Technology

Image: The Agilent Cary 60 UV-Vis Spectrophotometer is efficient, accurate and flexible, and is designed to meet immediate and future challenges (Photo courtesy of Agilent Technologies).

Automated Enzymatic Method Quantifies Pyruvate Kinase in Erythrocytes

 A deficiency of red blood cell (RBC) pyruvate kinase (PK), inherited as an autosomal recessive trait, is the most common cause of hereditary nonspherocytic hemolytic anemia (HSHA). The hemolysis is owing to the inability of the PK-deficient RBCs to maintain adequate quantities of ATP. More...
05 Mar 2020
Image: Schematic of the laser fabricated three-layer paper device for bacteria (Photo courtesy of University of Southampton)

Novel Point-of-Care Device Simultaneously Detects Bacterial Growth and Tests Antibiotic Susceptibility

 A novel paper-based point-of-care device that combines detection of pathogenic bacteria with determination of antibiotic susceptibility is expected to reduce the number of unnecessary antibiotic prescriptions and aid in the on-going struggle to prevent development of antibiotic resistance. More...
02 Mar 2020
Image: MACS Technology is a fast and gentle method for the isolation of viable and functionally active cells by magnetic labeling (Photo courtesy of University of Konstanz).

Fetal Cell-Based NIPT Demonstrated by Droplet Digital PCR

 Noninvasive testing techniques are often used for fetal diagnosis of genetic abnormalities, but are limited by certain characteristics, including non-informative results. Thus, novel methods of noninvasive definitive diagnosis of fetal genetic abnormalities are needed. More...
27 Feb 2020
Image: This side-by-side comparison of a breast tissue biopsy demonstrates some of the infrared-optical hybrid microscope’s capabilities. On the left, a tissue sample dyed by traditional methods. Center, a computed stain created from infrared-optical hybrid imaging. Right, tissue types identified with infrared data. The pink in this image signifies malignant cancer (Photo courtesy of Rohit Bhargava, PhD).

All-Digital Histopathology Attained by Infrared-Optical Hybrid Microscopy

 The gold standard of tissue pathology is to add dyes or stains so that pathologists can see the shapes and patterns of the cells under a microscope. However, it can be difficult to distinguish cancer from healthy tissue or to pinpoint the boundaries of a tumor, and in many cases diagnosis is subjective. More...
24 Feb 2020
Image: The photo shows a portable lab that plugs into a smartphone to diagnose diseases like malaria or coronavirus (Photo courtesy of Joseph Fuqua II, University of Cincinnati Creative Services)

Autonomous Microchannel Analyzer Combines with Smartphone for Off-site Disease Diagnostics

 A novel microchannel capillary flow assay platform for detection of pathogenic microorganisms or other antigens combines with a smartphone for display, data transfer, storage, and analysis. More...
18 Feb 2020
Image: Detection and quantification of procalcitonin and C‐reactive protein using detection of inflammatory biomarkers imager (DENIS) (Photo courtesy of Ecole Polytechnique Fédérale de Lausanne).

Optical Biosensor Reduces Time for Sepsis Diagnosis

 New point‐of‐care diagnostic devices are urgently needed for rapid and accurate diagnosis, particularly in the management of life‐threatening infections and sepsis, where immediate treatment is key. More...
12 Feb 2020
Image: The flexible NextSeq 550 System offers a seamless transition between high-throughput sequencing and array scanning (Photo courtesy of Illumina).

Novel Enrichment Technology Indicates High Performance for Multi-Cancer Detection

 Breast, lung, pancreatic, and prostate cancer make up 41% of the cancer incidence in the USA. Early detection and a deep understanding of each cancer remain critical for implementing the highest quality of care. More...
10 Feb 2020
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