We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Bioelectronic Devices Capture and Release Tumor Cells for Early Cancer Diagnosis

By LabMedica International staff writers
Posted on 11 Sep 2023
Print article
Image: Microfabricated bioelectronic device for cell capture and release (Photo courtesy of UPV/EHU)
Image: Microfabricated bioelectronic device for cell capture and release (Photo courtesy of UPV/EHU)

Metastasis, the spread of cancer cells from the primary tumor to distant organs, is the main cause of cancer-related deaths. Metastasis occurs when a cancer cell detaches from the initial tumor, travels through the bloodstream and lymphatic system, and invades other parts of the body. Collecting these circulating tumor cells non-invasively is crucial for understanding cell biology, as well as for cancer diagnosis, prognosis, and drug development. Traditional methods for gathering these cells in a usable form are time-consuming, given that the concentration of these cells in the bloodstream is incredibly low compared to other cell types.

Now, a group of researchers at the University of the Basque Country (UPV/EHU, Leioa, Spain) has designed a bioelectronic device that could revolutionize this process. The device featuring gold electrodes coated with a smart polymer not only captures but also releases cells in a controllable, non-destructive manner, while simultaneously tracking these activities through standard electrical readings. This is seen as a foundational step toward creating universal systems for early cancer detection. Previous biosensors designed for this purpose were less than ideal because they damaged cells during the capture and release process. To address this, the team integrated smart materials with bioelectronics, which involves the use of carbon-based semiconductors, for more accurate and less harmful cell capture and release mechanisms.

In their preliminary tests, the researchers did not use real patient samples but instead relied on commercial cells sustained in culture media. The results demonstrated that the device successfully captured and released these cells. The team is now in the process of customizing the polymer to interact specifically with different types of cells. Currently, the device is being used on esophageal cancer patient samples. Its role is to selectively accumulate cancer cells, making it easier to determine their concentration in the sample.

“We wanted to come up with a device capable of concentrating cancer cells in order to detect their concentration,” said Janire Sáez, Ikerbasque research professor in the UPV/EHU’s Microfluidics Cluster Group. These are the first steps towards developing platforms for cancer screening. This could be a good step forward because they generally involve low-cost technologies and can be mass-produced. The idea is to use this type of technology for early cancer diagnosis.”

Related Links:
UPV/EHU 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
TORCH Panel Rapid Test
Rapid TORCH Panel Test

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: The AI predictive model identifies the most potent cancer killing immune cells for use in immunotherapies (Photo courtesy of Shutterstock)

AI Predicts Tumor-Killing Cells with High Accuracy

Cellular immunotherapy involves extracting immune cells from a patient's tumor, potentially enhancing their cancer-fighting capabilities through engineering, and then expanding and reintroducing them into the body.... Read more

Microbiology

view channel
Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)

Integrated Solution Ushers New Era of Automated Tuberculosis Testing

Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more

Pathology

view channel
Image: The new AI tool can help beat brain tumors (Photo courtesy of Crystal Light/Shutterstock)

New AI Tool Classifies Brain Tumors More Quickly and Accurately

Precision in diagnosing and categorizing tumors is essential for delivering effective treatment to patients. Currently, the gold standard for identifying various types of brain tumors involves DNA methylation-based... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.