We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Breakthrough Test Detects Biological Markers Related to Wider Variety of Cancers

By LabMedica International staff writers
Posted on 21 Apr 2023
Print article
Image: A new test detects biological markers related to several types of cancer (Photo courtesy of Freepik)
Image: A new test detects biological markers related to several types of cancer (Photo courtesy of Freepik)

When assessing potential cancer cases, physicians rely on biomarker tests to aid in diagnosis. These tests, utilizing a testing system and patient samples, enable doctors to explore possible indicators and narrow down their search for the most accurate and effective treatment. Now, researchers have devised a novel test to identify biological markers associated with various cancer types.

A team of chemists at Florida State University (Tallahassee, FL, USA) has created a sensing platform made of a gold nanoparticle and dye-labeled peptide molecules. These components are linked by chemical bonds, with the gold nanoparticle preventing the dye from emitting light under UV exposure. When a patient sample containing the enzyme MMP-14 – a biomarker for multiple cancer types, most commonly breast cancer – is introduced, it breaks the peptide bonds, separating the dye-containing fragment from the gold. In the absence of gold to absorb the dye's energy, the sample starts to emit light. The intensity of this light emission depends on the enzyme concentration and interaction duration. By analyzing this light, researchers can determine the presence and levels of a cancer marker in the sample.

Although there are already numerous tests to identify cancer in patients, this research represents an initial step towards developing a method capable of detecting a broader range of cancers. The research team has tested their system with the MMP-14 enzyme but intends to expand their efforts by pairing more peptide chains with other enzyme cancer markers. This advancement could eventually enable scientists to use a single test to simultaneously screen for various cancers. In addition to its diagnostic applications, the study also provides further insights into enzyme interactions with peptide-bound nanoparticles and the impact of enzyme addition on the testing system.

“Better tools for detecting cancer mean more effective treatment for patients,” said study co-author Hedi Mattoussi, a professor in the FSU Department of Chemistry and Biochemistry. “Our goal in this research was to build a biosensor that would light up in the presence of cancer markers, offering another tool for the ongoing problem of detecting this disease.”

Related Links:
Florida State University 

Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article


Clinical Chemistry

view channel
Image: The new ADLM guidance will help healthcare professionals navigate respiratory virus testing in a post-COVID world (Photo courtesy of 123RF)

New ADLM Guidance Provides Expert Recommendations on Clinical Testing For Respiratory Viral Infections

Respiratory tract infections, predominantly caused by viral pathogens, are a common reason for healthcare visits. Accurate and swift diagnosis of these infections is essential for optimal patient management.... Read more

Molecular Diagnostics

view channel
Image: The HelioLiver Dx test has met the coprimary and secondary study endpoints in the CLiMB trial (Photo courtesy of Helio Genomics)

Blood-Based Test Outperforms Ultrasound in Early Liver Cancer Detection

Patients with liver cirrhosis and chronic hepatitis B are at a higher risk for developing hepatocellular carcinoma (HCC), the most prevalent type of liver cancer. The American Association for the Study... Read more


view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more


view channel
Image: The POC PCR test shortens time for STI test results (Photo courtesy of Visby Medical)

POC STI Test Shortens Time from ED Arrival to Test Results

In a 2024 sexually transmitted infections (STIs) surveillance report by the World Health Organization (WHO), over 2.5 million cases were recorded, alongside a rise in the inappropriate use of antibiotics... Read more


view channel
Image: For 46 years, Roche and Hitachi have collaborated to deliver innovative diagnostic solutions (Photo courtesy of Roche)

Roche and Hitachi High-Tech Extend 46-Year Partnership for Breakthroughs in Diagnostic Testing

Roche (Basel, Switzerland) and Hitachi High-Tech (Tokyo, Japan) have renewed their collaboration agreement, committing to a further 10 years of partnership. This extension brings together their long-standing... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.