We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Novel Biosensor Detects Neurogenerative Disease Proteins

By LabMedica International staff writers
Posted on 17 Jul 2023
Print article
Image: A single sensor combines multiple advanced technologies to diagnose neurodegenerative diseases (Photo courtesy of EPFL)
Image: A single sensor combines multiple advanced technologies to diagnose neurodegenerative diseases (Photo courtesy of EPFL)

The struggle to diagnose neurodegenerative diseases (NDDs), including Alzheimer's and Parkinson's, has primarily been due to the absence of reliable diagnostic tools for the early detection and tracking of disease progression. One main characteristic of neurodegeneration is protein misfolding, recognized as a significant event in the advancement of the disease. The theory is that in the initial stages, normal proteins misfold into oligomers and, in later stages, into fibrils. These misshaped protein aggregates circulate in the brain and body fluids, as well as accumulate as deposits in the brains of those who died from NDDs. However, the development of tools to identify these disease markers or biomarkers has remained unresolved until now due to various barriers, including the limitations of current technology to accurately distinguish and quantify different protein aggregates.

Researchers at EPFL (Lausanne, Switzerland) have now made a significant breakthrough in NDD diagnosis by combining multiple advanced technologies into a single system. This innovative system dubbed the ImmunoSEIRA sensor, employs biosensing technology to detect and identify misfolded protein biomarkers associated with NDDs. In addition, the system leverages the power of artificial intelligence (AI), utilizing neural networks to quantify disease stages and progression. This groundbreaking advancement offers hope for not only early NDD detection and monitoring but also for evaluating treatment options at different disease progression stages.

The researchers created this sophisticated NDD biomarker sensor by combining various scientific fields: protein biochemistry, optofluidics, nanotechnology, and AI. The ImmunoSEIRA sensor uses a technique called surface-enhanced infrared absorption (SEIRA) spectroscopy, allowing scientists to identify and analyze the structure of specific disease-linked molecules or biomarkers tied to NDDs. The sensor features a unique immunoassay to identify and capture these biomarkers with utmost precision. The ImmunoSEIRA sensor utilizes gold nanorod arrays with antibodies for precise protein detection and facilitates real-time specific capture and structural analysis of target biomarkers from minute samples. AI-driven neural networks are employed to identify the presence of specific misfolded protein forms - the oligomeric and fibrillary aggregates, providing an unprecedented level of detection precision as the diseases progress.

The EPFL researchers went on to demonstrate that the ImmunoSEIRA sensor can be applied in real clinical settings, i.e., in biofluids. They successfully identified the unique signature of abnormal fibrils, a key NDD indicator, even in complex fluids such as human cerebrospinal fluid (CSF). This study's results mark a significant leap in the domains of biosensing, infrared spectroscopy, nanophotonics, and NDD biomarkers. The introduction of the AI-assisted ImmunoSEIRA sensor is a positive development for early NDD detection, disease monitoring, and drug efficacy evaluation, fulfilling the urgent need for prompt intervention and treatment of NDDs.

“Since the disease process is tightly associated with changes in protein structure, we believe that structural biomarkers, especially when integrated with other biochemical and neurodegeneration biomarkers, could pave the way for more precise diagnosis and monitoring of disease progression,” said Professor Hilal Lashuel.

Related Links:

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
POCT Fluorescent Immunoassay Analyzer
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article



view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more


view channel
Image: The photoacoustic spectral response sensing instrument is based on low-cost laser diodes (Photo courtesy of Khan et al., doi 10.1117/1.JBO.29.1.017002)

Compact Photoacoustic Sensing Instrument Enhances Biomedical Tissue Diagnosis

The pursuit of precise and efficient diagnostic methods is a top priority in the constantly evolving field of biomedical sciences. A promising development in this area is the photoacoustic (PA) technique.... Read more


view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.