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Hematology

Image: The Cyan ADP flow cytometer (Photo courtesy of Beckman Coulter).

Specific RUNX1 Mutations Cause Different Disease Types

Mutations of the hematopoietic master regulator RUNX1 are associated with acute myeloid leukemia, familial platelet disorder and other hematological malignancies whose phenotypes and prognoses depend upon the class of the RUNX1 mutation. More...
28 Jan 2021
Image: Tryptophan metabolism is dysregulated in individuals with Fanconi anemia (Photo courtesy of Cincinnati Children’s Hospital Medical Center).

Tryptophan Metabolism Is Dysregulated in Individuals with Fanconi Anemia

Fanconi anemia (FA) is a complex genetic disorder frequently associated with progressive marrow failure and a strong predisposition to early malignancies, particularly squamous cell carcinomas and hepatocellular carcinomas. More...
20 Jan 2021
Image: The TEG 5000 Thrombelastograph Hemostasis Analyzer system is a diagnostic instrument that provides comprehensive whole blood hemostasis testing that can help assess bleeding and thrombotic risks, and also monitor antithrombotic therapies (Photo courtesy of Haemonetics).

Coagulopathy Testing Linked to Better COVID-19 Outcomes

Significant infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to development of coagulopathy, most typically a hypercoagulable state. In addition to thrombotic conditions, coronavirus disease 2019 (COVID-19) patients may develop hemorrhagic complications, which have been under recognized or inadequately emphasized in prior studies. More...
19 Jan 2021
Image: An newborn infant at 26 weeks: for most preterm babies, a higher hemoglobin threshold for red-cell transfusion did not improve survival without neurodevelopmental impairment (Photo courtesy of Jaimie and John Florio)

Preterm Infants Tolerate Restrictive Red Blood Cell Transfusion Strategy

Very preterm infants (born before 29 weeks of pregnancy) and those weighing less than 1,000 grams are at high risk for anemia because of their early stage of development, reduced ability to produce red blood cells, and need for blood sampling as part of their intensive medical care. More...
11 Jan 2021
Image: Electron micrograph of an hematopoietic stem cell that can be obtained from the umbilical cord blood, adult bone marrow, and peripheral blood (Photo courtesy of Donald W. Fawcett, MD).

Next Generation Sequencing Developed for Monitoring of Mixed Chimerism

Hematopoietic stem-cell transplantation (HSCT) is the only curative treatment for patients with hematological malignant and non-malignant diseases. There are more than 50,000 stem cell transplants are carried out annually worldwide and the number is increasing. More...
07 Jan 2021
Image: Hematologic Reference Intervals Defined for Newborns on the XN-1000 Automated Hematology Analyzer (Photo courtesy of Sysmex Corporation).

Automated Hematologic Reference Intervals Defined for Newborns

Laboratory tests leverage 60% to 70% of medical decisions and one of the most often ordered and impactful tests is the complete blood count (CBC). These decisions require that clinicians have a standard for interpreting laboratory test results for their patients. More...
05 Jan 2021
Image: Reduced prevalence of SARS-CoV-2 infection in blood group O individuals reported in Denmark (Photo courtesy of Odense University Hospital).

Blood Type Linked to Risk of COVID-19 Infection Severity

Identification of risk factors for contracting and developing serious illness following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of paramount interest. Development of COVID-19 is associated with age, sex, and comorbidities, such as cardiovascular diseases, although severe disease is not limited to these risk groups. More...
04 Jan 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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