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Hematology

Image: The HYDRASYS 2 Electrophoresis Automated System (Photo courtesy of Sebia).

Paraproteins Identification Methods Compared for Monoclonal Gammopathies

Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. More...
18 Mar 2021
Image: Model of clonal hematopoiesis in normal and inflammatory conditions. In a normal person, hematopoietic stem cells (HSCs) will differentiate and self-renew over the course of a lifetime to replenish the blood system. HSCs will acquire somatic mutations as a result of proliferative stress (Photo courtesy of University of California Irvine).

Clonal Hematopoiesis and Recurrent Mutations Identified in Blood Cancers

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by detectable hematopoietic-associated gene mutations in a person without evidence of hematologic malignancy. Somatic mutations at hotspots (genetic loci observed to be frequently mutated across cancer patients) often drive or contribute to cancer pathogenesis. More...
16 Mar 2021
Image: The Wallac 1420 Victor 2 Multi-Label Microplate Reader (Photo courtesy of  Perkin Elmer).

COVID-19 Induces a Hyperactive Phenotype in Circulating Platelets

Coronavirus Disease 2019 (COVID-19) is characterized by a marked pro-inflammatory response with fever, elevated inflammatory markers, and clinical and radiological features of pneumonitis being evident among affected individuals. More...
15 Mar 2021
Image: Workflow for hemoglobin estimation using an automated microscope (Photo courtesy of Sigtuple Technologies).

Hemoglobin Levels Measured with AI Microscope, Microfluidic Chips

A complete blood count can help ascertain the health of a patient and typically includes an estimate of the hemoglobin concentration, which can indicate several conditions, including anemia, polycythemia, and pulmonary fibrosis. More...
10 Mar 2021
Image: Schematic diagram of a neutrophil activation signature predicting critical illness and mortality in COVID-19 (Photo courtesy of Yale School of Medicine).

Blood Tests Offer Early Indicator of Severe COVID-19

For most patients, COVID-19 manifests as an upper respiratory tract infection that is self-limited. However, the progression of COVID-19 in a large subset of patients to respiratory distress, multiorgan failure, and death has resulted in an enormous global impact. More...
09 Mar 2021
Image: Schematic diagram of Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K matched transfusions (Photo courtesy of The Children’s Hospital of Philadelphia).

Rh Alloimmunization Explored in Chronically Transfused Thalassemia Patients

Chronic life-long transfusions are often required for patients with severe thalassemia to provide normal red blood cells and to suppress the patients’ own ineffective erythropoiesis. Cumulative exposure increases the risk for red cell alloimmunization and subsequent delayed hemolytic transfusion reactions (DHTRs). More...
01 Mar 2021
Image: TruSight Oncology 500 is a next-generation sequencing (NGS) assay that enables in-house comprehensive genomic profiling of tumor samples it accurately measures key current immuno-oncology biomarkers: microsatellite instability (MSI) and tumor mutational burden (TMB) (Photo courtesy of Illumina).

Next Generation Sequencing Finds More Gene Mutations for Leukemia

Myeloid malignancies are characterized by uncontrolled proliferation and/or defects in differentiation of abnormal myeloid progenitor cells. Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are often thought to be precursors to a higher grade myeloid malignancies, namely acute myeloid leukemia (AML). More...
18 Feb 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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