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Hematology

Image: B cell–activating factor modulates the factor VIII immune response in hemophilia A (Photo courtesy of Children’s Hospital of Philadelphia)

Cytokine Target Identified for Treatment-Resistant Hemophilia A

Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history. More...
04 May 2021
Image: The CytoFLEX Flow Cytometer has a large dynamic range to resolve dim and bright populations in the same sample (Photo courtesy of Beckman Coulter)

Synovial Fluid Neutrophils Phenotyped in Oligoarticular Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is an inflammatory rheumatic joint disease affecting children. Despite disease onset being at a young age, symptoms may be lifelong and include irreversible joint damage or growth disturbances. More...
29 Apr 2021
Image: The QX200 Droplet Digital Polymerase Chain Reaction (PCR) Systems provide ultrasensitive and absolute nucleic acid quantification. (Photo courtesy of Bio-Rad)

Digital PCR Improves BCR-ABL1 Detection in Chronic Myeloid Leukemia

Specific targeting of the Bcr-Abl1 enzyme by tyrosine kinase inhibitors (TKI) revolutionized the management of chronic myeloid leukemia (CML) to the point that TKIs can offer near normal life expectancy for CML patients. More...
22 Apr 2021
Image: BD FACSCanto II flow cytometer (Photo courtesy of BD Biosciences)

Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized

Monoclonal B-cell lymphocytosis (MBL) was initially proposed to recognize patients with a monotypic B cell population identified by peripheral blood (PB) flow cytometry (FC) that did not meet numerical criteria for chronic lymphocytic leukemia (CLL). More...
21 Apr 2021
Image: Histology comparison of airway features in (A) a healthy individual and (B) in a patient with chronic obstructive pulmonary disease where airways are narrowed by infiltration of inflammatory cells, mucosal hyperplasia, and deposition of connective tissue in the peribronchiolar space (Photo courtesy of University of Leuven)

Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD

Chronic obstructive pulmonary disease (COPD) is one of the common chronic airway obstructive diseases, characterized by persistent respiratory symptoms and airflow limitation. In acute exacerbation stage (AECOPD), patients developed respiratory failure often have circulatory and coagulation dysfunction, which was considered the cause of thrombosis events in the patients. More...
14 Apr 2021
Image: The BD FACSAria III sorter is equipped with five lasers, 17 fluorescence channels and two channels for Forward Scatter and Side Scatter (Photo courtesy of BD Biosciences)

Genome Sequencing Identifies Myeloma Precursor Disease with Progression Risk

Multiple myeloma (MM) is the second most common hematological malignancy and is consistently preceded by the asymptomatic expansion of clonal plasma cells, termed either monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). More...
08 Apr 2021
Image: The ERMA PCE-210N fully automatic cell counter (Photo courtesy of ERMA)

Flow-Cytometric Expression of Endoglin Assessed in B-Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a malignant disorder representing clonal expansion and arrest of maturation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. The incidence of ALL generally follows a bimodal distribution, with its first peak occurring in childhood and the second around the age of 50. More...
01 Apr 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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