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Molecular Diagnostics

Image: Single nucleotide polymorphism: The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (Photo courtesy of Marshall University).

Dual Nucleic Acid Template Assay Developed for Cancer

 Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing or second-generation sequencing. More...
16 Jan 2020
Image: Nextera XT DNA Library Preparation Kit (Photo courtesy of Illumina).

Extrachromosomal Circular DNA Identified in Maternal Plasma

 Circular cell-free DNA of both maternal and fetal origin can be identified in the plasma of pregnant women, pointing to a possible new type of biomarker for noninvasive prenatal testing (NIPT). More...
16 Jan 2020
Image: A dried flower bud of the Cannabis plant. The cannabis' flowers contain many different psychoactive compounds that are used for recreational or medicinal purposes (Photo courtesy of Wikimedia Commons)

A Sweat-Based On-Site Immunoassay for Monitoring Marijuana Use

 A novel sweat-based skin test enables on-site testing for tetrahydrocannabinol (THC), the main psychoactive component found in marijuana plants (Cannabis). More...
16 Jan 2020
Image: Schematic diagram of, circulating tumor DNA (ctDNA); circulating tumor cell (CTC); cell-free DNA (cfDNA) in the peripheral blood stream of a colon cancer patient (Photo courtesy of Oncology Letters)

Tumor DNA Platform Classifies Colorectal Cancer

 Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. More...
15 Jan 2020
Image: Structure of the UCH-L1 protein (Photo courtesy of Wikimedia Commons)

Biomarker-Based Blood Test Does Not Completely Replace CT Scan for Diagnosis of Elderly Concussion Patients

 A recent study confirmed that the GFAP/UCH-L1 blood test could predict with 100% accuracy which elderly concussion patients did not have brain tissue damage and were not in need of a CT scan. More...
14 Jan 2020
Image: The ABI PRISM 3500 Genetic Analyzer Platform (Photo courtesy of Applied Biosystems)

Multiplex Nested Polymerase Chain Reaction Developed for Congenital Infections

 Infections are the leading cause of perinatal mortality in low- and middle-income countries, which have a higher prevalence of infections, and are responsible for 50% of infant deaths in the first year of life. Definitive diagnosis of congenital and perinatal infections is largely dependent upon the results of laboratory tests. More...
13 Jan 2020
Image: Photomicrograph of bone marrow aspirate of a pediatric patient with acute myeloid leukemia (Photo courtesy of St. Jude Children's Research Hospital).

Biomarker Predicts Prognosis in Acute Myeloid Leukemia Patients

 Acute myeloid leukemia (AML) is the most prevalent adult acute leukemia, which is characterized by abnormal proliferation and the accumulation of immature myeloid precursor cells in the bone marrow, peripheral blood, and even some tissues, contributing to the destruction of the hematopoietic system. More...
13 Jan 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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