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Clinical Chemistry

Image: The Orbitrap Fusion Lumos Tribrid Mass Spectrometer (Photo courtesy of Thermo Fisher Scientific).

Mass Spectrometer Test Developed for Multiple Myeloma

The M-proteins are established markers for plasma cell disorders including multiple myeloma and are a key analyte for diagnosis and management of that disease. Electrophoresis-based assays are commonly used to measure levels of these proteins, with higher levels indicating a higher disease burden, but such techniques are fairly time consuming and not highly sensitive. More...
03 Mar 2018
Image: Blood samples used to assess traumatic brain injury using the Brain Trauma Indicator test (Photo courtesy of Banyan Biomarkers).

Blood Test Approved for Adult Traumatic Brain Injury

In 2013, there were approximately 2.8 million traumatic brain injuries (TBI)-related emergency department visits, hospitalizations and deaths in the USA. Of these cases, TBI contributed to the deaths of nearly 50,000 people. More...
01 Mar 2018
Image: Rings of Plasmodium falciparum in a stained thin blood smear (Photo courtesy of the CDC).

AKI Biomarker Described for Pediatric Malaria

Acute kidney injury (AKI) is an important complication in severe malaria that is associated with increased mortality in both pediatric and adult populations. However, until recently, the incidence of AKI in pediatric malaria was under-appreciated as few children develop signs of overt renal failure and creatinine testing is not routinely available in resource-constrained settings. More...
28 Feb 2018
Image: A Matrix-Assisted Laser Desorption/Ionization (MALDI) time-of-flight mass spectrometer (Photo courtesy of JEOL).

Plasma Markers Predict Brain Amyloid Burden in AD

Aggregation and accumulation of beta-amyloid (Aβ), particularly Aβ42, is implicated in the pathogenesis of Alzheimer's disease (AD) with overproduction in autosomal-dominant AD and impaired clearance in the presence of amyloidosis contributing to the cause of AD. More...
23 Feb 2018
Image: The Nephelometer analyzer BN II (Photo courtesy of Siemens Healthcare).

C-Reactive Protein Assessed for Albuminuria Severity

Diabetes is a major cause of early morbidity and mortality in the world and is the leading cause of renal failure, non-traumatic amputations and blindness in adults. Chronic hyperglycemia causes irreversible structural and functional changes in cells leading to the development of microvascular and macrovascular complications. More...
21 Feb 2018
Image: An immunohistochemistry of anti-Alpha-Fetoprotein (AFP) antibody on liver tissue from a human hepatocellular carcinoma patient (Photo courtesy of Arigo Biolaboratories).

Blood Test Plus Ultrasound Enhances Liver Cancer Detection

While the incidence of most cancers is decreasing in the USA the incidence of liver cancer has increased by 2.7% a year over the last 10 years, which is estimated at about 40,700 new cases of liver cancer that will be diagnosed in the USA in 2018. More...
20 Feb 2018
Image: The Multiskan FC microplate photometer (Photo courtesy of Thermo Fisher Scientific).

Blood Test Helps Identify CV Patients Most at Risk

A new blood test could provide a clue as to why some patients are at higher risk of cardiovascular disease risk after suffering a heart attack, which may help scientists to identify new targets for reducing the risk and eventually lead to more effective treatments. More...
19 Feb 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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