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BioResearch

Image: Electron microscope image of a pancreatic beta cell, showing malformed mitochondria resulting from calcium leakage; the purple circle represents an insulin granule (Photo courtesy of Dr. Gaetano Santulli, Columbia University Medical Center).

Leaky Calcium Channels Promote Development of Diabetes

Chronic leakage from cellular calcium channels has been linked to a rare type of exercise-induced cardiac arrest and has been shown to cause glucose intolerance, suggesting that it might be involved in the development of type II diabetes.  More...
19 Apr 2015
Image: Cancer cells, left, were pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated (Photo courtesy of the Weizmann Institute of Science).

Prevention of ERK Nuclear Translocation Blocks Cancer Proliferation in Animal Models

A team of cell biologists has shown that the cancer promoting effects of ERK dysregulation can be blocked by low molecular weight drugs that prevent translocation of this kinase from the cells' cytoplasm into the nucleus.  More...
15 Apr 2015
Image: Structure of the CCNA2 (cyclin A2) protein (Photo courtesy of Wikimedia Commons).

Bile Acids Regulate Expression of a Tumor Suppressive MicroRNA

A recent paper explained how the tumor suppressive microRNA miR-22 is regulated in cells lining the gastrointestinal tract and how defective regulation leads to various types of cancer.  More...
14 Apr 2015

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center and NanoString Technologies will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology and to extend targeted therapeutics programs.  More...
13 Apr 2015
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease in a mouse model.  More...
13 Apr 2015
Image: Fast functional photoacoustic microscopy of the mouse brain. Figure (d) shows a representative x-y projected brain vasculature image through an intact skull. Figure (e) shows a representative enhanced x-z projected brain vasculature image. Figure (f) shows photoacoustic microscopy of oxygen saturation of hemoglobin in the mouse brain, acquired by using the single-wavelength pulse-width-based method with two lasers (Photo courtesy of Washington University).

Photoacoustic Microscopy Enables Rapid Imaging of the Brain's Oxygen Metabolism

Photoacoustic microscopy is a novel imaging technique that was exploited by researchers to view the vascular morphology, blood oxygenation, blood flow, and oxygen metabolism in both resting and stimulated states in the mouse brain.  More...
12 Apr 2015

Drug Development Acquisition Focuses on Treatment for Movement Disorders

The purchase of a biomedical company that develops drugs for treatment of hyperkinetic movement disorders by one of the world's largest producers of generic drugs is expected to strengthen the generics manufacturer's position in the market for central nervous system condition treatments.  More...
12 Apr 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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