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BioResearch

Image: A space-filling model of firefly luciferin. Color coding: yellow = sulfur; blue = nitrogen; black = carbon; red = oxygen; white = hydrogen (Photo courtesy of Wikimedia Commons).

Diagnosing Liver Cancer Using Genetically Modified Probiotic Bacteria

A genetically engineered variety of the probiotic bacterium Escherichia coli Nissle 1917 was used to generate a luminescent diagnostic biomarker that could be detected in the urine of rodents with liver tumors.   More...
07 Jun 2015
Image: Zebrafish embryos with fluorescent blood vessels helped solve the mystery regarding the origin of the lymphatic system (Photo courtesy of the Weizmann Institute of Science).

Research on Zebrafish Embryos Reveals Origin of the Lymphatic System

A team of developmental biologists working with a zebrafish embryo model system has located the site of origin of the lymphatic system and identified a gene critical to the differentiation of stem cells into mature lymphatic cells.  More...
03 Jun 2015
Image: In rheumatoid arthritis, fibroblast-like synoviocytes—specialized cells that line the inside of joints—invade and destroy the affected joint\'s cartilage. Ezrin, which plays in important role in cell adhesion and migration, is shown in green, actin in red, and the cells\' nuclei in blue (Photo courtesy of Dr. Karen Doody and Dr. Bill Kiosses, La Jolla Institute of Allergy and Immunology).

Treating New Rheumatoid Arthritis Drug Target Would Not Increase Immune Suppression

Treatment directed at a newly identified drug target in rheumatoid arthritis would prevent damage to the joints while not increasing the immune suppression that is induced by the action of currently used therapies.  More...
03 Jun 2015
Image: Micrograph of individual cancer cells that were isolated according to their motility. The cell on the left is less likely to metastasize (Photo courtesy of University of Michigan).

Sorting and Selecting Cancer Cells by Their Motility Will Advance Understanding of Metastatic Processes

In order to develop a better understanding of the mechanisms that cause some cancer cells to break away from the primary tumor and migrate to other parts of the body, a team of cancer researchers has created an instrument for sorting and selecting cancer cells based on their motility.  More...
03 Jun 2015
Image: Structure of the DDX3X protein (Photo courtesy of Wikimedia Commons).

Experimental Drug Blocks Critical Lung Cancer DNA Repair Enzyme

A low molecular weight drug—effective on its own and in combination with radiation therapy—has been developed that interferes specifically with the cell cycle of lung cancer cells.  More...
02 Jun 2015
Image: Micrograph shows marrow-infiltrating lymphocytes in cell culture (Photo courtesy of Dr. Kimberly Noonan, Johns Hopkins University).

Preliminary Clinical Trial Demonstrates Feasibility of Treating Multiple Myeloma with the Patient's Own Marrow-Infiltrating Lymphocytes

Results of a small clinical trial support the feasibility of using a multiple myeloma patient's marrow-infiltrating lymphocytes as the basis for adoptive T cell therapy.  More...
01 Jun 2015

Target Molecule for Treatment of Multiple Sclerosis Identified

A protein marker expressed by a subset of human lymphocytes, which is capable of crossing the blood brain barrier and causing inflammation and damage to the neural tissues of individuals with multiple sclerosis, has been singled out as a potential drug target for treatment of the disease.  More...
01 Jun 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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